Signal recognition particle

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The Signal recognition particle is a key complex for the translocation of proteins across the cell membrane.

The complex is composed of the following proteins and RNA:

Key publications

Bertrand Beckert, Alexej Kedrov, Daniel Sohmen, Georg Kempf, Klemens Wild, Irmgard Sinning, Henning Stahlberg, Daniel N Wilson, Roland Beckmann
Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions.
Nat. Struct. Mol. Biol.: 2015, 22(10);767-73
[PubMed:26344568] [] [DOI] (I p)

Martin R Pool
Signal recognition particles in chloroplasts, bacteria, yeast and mammals (review).
Mol. Membr. Biol.: 2005, 22(1-2);3-15
[PubMed:16092520] [] (P p)

Shu-ou Shan, Peter Walter
Co-translational protein targeting by the signal recognition particle.
FEBS Lett.: 2005, 579(4);921-6
[PubMed:15680975] [] [DOI] (P p)

Joen Luirink, Irmgard Sinning
SRP-mediated protein targeting: structure and function revisited.
Biochim. Biophys. Acta: 2004, 1694(1-3);17-35
[PubMed:15546655] [] [DOI] (P p)

Klemens Wild, Mario Halic, Irmgard Sinning, Roland Beckmann
SRP meets the ribosome.
Nat. Struct. Mol. Biol.: 2004, 11(11);1049-53
[PubMed:15523481] [] [DOI] (P p)

Kunio Yamane, Keigo Bunai, Hiroshi Kakeshita
Protein traffic for secretion and related machinery of Bacillus subtilis.
Biosci. Biotechnol. Biochem.: 2004, 68(10);2007-23
[PubMed:15502345] [] (P p)

Jennifer A Doudna, Robert T Batey
Structural insights into the signal recognition particle.
Annu. Rev. Biochem.: 2004, 73;539-57
[PubMed:15189152] [] [DOI] (P p)

Kiyoshi Nagai, Chris Oubridge, Andreas Kuglstatter, Elena Menichelli, Catherine Isel, Luca Jovine
Structure, function and evolution of the signal recognition particle.
EMBO J.: 2003, 22(14);3479-85
[PubMed:12853463] [] [DOI] (P p)

H-G Koch, M Moser, M Müller
Signal recognition particle-dependent protein targeting, universal to all kingdoms of life.
Rev. Physiol. Biochem. Pharmacol.: 2003, 146;55-94
[PubMed:12605305] [] [DOI] (P p)

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