yrkP

168

two-component response regulator ([wiki|OmpR family])

locus: BSU_26430

Molecular weight: 26.65 kDa

pI: 5.69

Protein length: 231 aa

Gene length: 696 bp

function: unknown

product: two-component response regulator ([wiki|OmpR family])

essential: no

synonyms: yrkP

List of homologs in different organisms, belongs to COG0745 (Galperin et al., 2021)

Gene

Coordinates: 2,704,435  2,705,130

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The protein

Protein family

• [wiki|OmpR family] of two-component response regulators

[wiki|Domains]

• [wiki|Response regulatory domain] (aa 4-116) (according to UniProt)

Structure

• [PDB|2OQR] (RegX3 from Mycobacterium tuberculosis, 38% identity) [pubmed|17942407]
• [AF|P54443]

Modification

• phosphorylated by [protein|8A38FEFAA0FF91D989B77D40CBB3741902DC9D67|yrkQ] on an Asp residue

Effectors of protein activity

• phosphorylation likely affects DNA-binding activity

Expression and Regulation

Operons

• genes: [gene|1582F9E6510C4FA87B3A5F3F4A7F39008C654AA9|yrkP]-[gene|8A38FEFAA0FF91D989B77D40CBB3741902DC9D67|yrkQ]-[gene|E0DF6DE230AD0B632EEC0A1FB11EB32E59BD573E|yrkR]

  description: [Pubmed|18175906]

  regulatory mechanism

  • [protein|1582F9E6510C4FA87B3A5F3F4A7F39008C654AA9|yrkP]: activation, [Pubmed|18175906], in [regulon|protein:1582F9E6510C4FA87B3A5F3F4A7F39008C654AA9|yrkP regulon]

Biological materials

Mutant

• BKE26430 ([gene|1582F9E6510C4FA87B3A5F3F4A7F39008C654AA9|yrkP]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE26430 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGTCTCTCTCACCTCATG,  downstream forward: _UP4_CGATTTGGCGCATCTTAAAT
• BKK26430 ([gene|1582F9E6510C4FA87B3A5F3F4A7F39008C654AA9|yrkP]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK26430 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGTCTCTCTCACCTCATG,  downstream forward: _UP4_CGATTTGGCGCATCTTAAAT

References

• 10094672,18175906,23504016,17942407