rex
168
transcriptional repressor of anaerobically expressed genes involved in anaerobic respiration and fermentation
locus
BSU_05970
Molecular weight
23.95 kDa
pI
6.77
function
regulation of fermentation and anaerobic respiration
product
transcriptional repressor
essential
no
synonyms
rex, ydiH
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2344 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
647,091 → 647,738
Phenotypes of a mutant
inactivation of ''[gene|B5EF521437323EF43F08E5EFDB5C798616CA499A|rex]'' reduces sporulation efficiency to 9.2% that of wild type cells [Pubmed|26735940]
inactivation of ''[gene|B5EF521437323EF43F08E5EFDB5C798616CA499A|rex]'' confers resistance to high concentrations of Zn(II) [Pubmed|27935957]
The protein
Protein family
transcriptional regulatory rex family (single member, according to UniProt)
Structure
[PDB|2VT2], [PDB|2VT3]
[AF|O05521]
Effectors of protein activity
NADH (indication of low oxygen concentration) releases Rex from DNA [Pubmed|18485070], Rex has a very high affinity for NADH
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Biological materials
Mutant
MGNA-C201 (ydiH::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2199 NBRP B. subtilis, Japan]
LUW292 (erm), GP834 (erm), both available in the [wiki|Stülke] lab
BKE05970 (Δ[gene|B5EF521437323EF43F08E5EFDB5C798616CA499A|rex]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE05970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CGGAATTTTTGATTGATCCT, downstream forward: _UP4_TAGAGGGAAAGGAGGAGCCC
BKK05970 (Δ[gene|B5EF521437323EF43F08E5EFDB5C798616CA499A|rex]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK05970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CGGAATTTTTGATTGATCCT, downstream forward: _UP4_TAGAGGGAAAGGAGGAGCCC
labs
[wiki|Claes von Wachenfeldt], Lund University, Sweden [http://aron.ldc.lu.se/kundwebb/cellorg/mibiol/research/wachen/index.htm Homepage]
References
Reviews
Original Publications
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Time of last update: 2024-04-24 09:21:06
Author of last update: Melvin.boenninger