SubtiWiki - User contributions [en]

RsbR

2009-06-12T12:42:12Z

Janpf: /* Extended information on the protein */

* '''Description:''' activator of RsbT kinase activity, part of the stressosome <br/><br/>

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''rsbR''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ycxR, rsbRA''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || activator of RsbT kinase activity
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || control of SigB activity
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 30 kDa, 4.731
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 822 bp, 274 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ndoA]]'', ''[[rsbS]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB12274]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:rsbR_context.gif]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|}

__TOC__

<br/><br/>

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU04670

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/rsbRSTUVW-sigB-rsbX.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11090]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:'''

* '''Paralogous protein(s):''' [[RsbRB]], [[RsbRC]], [[RsbRD]], [[YtvA]]

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:''' RsbRA is composed of an N-terminal nonheme globin domain and a highly conserved C-terminal STAS (Sulphate Transporter and AntiSigma factor antagonist) domain. The C-terminal STAS domain is the target of the serine/threonine-specific kinase RsbT (see below).

* '''Modification:''' RsbRA: Thr-171 and Thr-205

phosphorylation on Thr-186 (RsbRB) [http://www.ncbi.nlm.nih.gov/sites/entrez/17218307 PubMed], phosphorylation on Thr-171 (RsbRA) [http://www.ncbi.nlm.nih.gov/pubmed/17726680 PubMed]

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:''' [[RsbR]]-[[RsbT]], [[RsbR]]-[[RsbS]]

* '''Localization:'''

=== Database entries ===

* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2BNL 2BNL] (N-terminal domain), [http://www.rcsb.org/pdb/explore.do?structureId=3VY9 3VY9] (complete stressosome)

* '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/P42409 P42409]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu+BSU04670]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''[[rsbR]]-[[rsbS]]-[[rsbT]]-[[rsbU]]-[[rsbV]]-[[rsbW]]-[[sigB]]-[[rsbX]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/8002610 PubMed]

* '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/8002610 PubMed]

* '''Regulation:'''

* '''Regulatory mechanism:'''

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

* [[Bill Haldenwang]], San Antonio, USA
* [[Chet Price]], Davis, USA [http://foodscience.ucdavis.edu/price_lab/pricelab.html homepage]
* [[Rick Lewis]], Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/r.lewis homepage]

=Your additional remarks=

=References=

<pubmed> 12950928, 15466036, 9179850, 8955331, 18832644 ,17726680 ,17218307 </pubmed>
# Author1, Author2 & Author3 (year) Title ''Journal'' '''volume:''' page-page. [http://www.ncbi.nlm.nih.gov/sites/entrez/PMID PubMed]

RsbR

2009-06-12T12:23:46Z

Janpf: /* Extended information on the protein */

* '''Description:''' activator of RsbT kinase activity, part of the stressosome <br/><br/>

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''rsbR''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ycxR, rsbRA''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || activator of RsbT kinase activity
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || control of SigB activity
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 30 kDa, 4.731
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 822 bp, 274 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ndoA]]'', ''[[rsbS]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB12274]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:rsbR_context.gif]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|}

__TOC__

<br/><br/>

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU04670

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/rsbRSTUVW-sigB-rsbX.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11090]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:'''

* '''Paralogous protein(s):''' [[RsbRB]], [[RsbRC]], [[RsbRD]], [[YtvA]]

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:''' N-terminal nonheme globin domain, C-terminal STAS (Sulphate Transporter and AntiSigma factor antagonist) domain

* '''Modification:''' phosphorylation on Thr-186 [http://www.ncbi.nlm.nih.gov/sites/entrez/17218307 PubMed], phosphorylation on Thr-171 [http://www.ncbi.nlm.nih.gov/pubmed/17726680 PubMed]

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:''' [[RsbR]]-[[RsbT]], [[RsbR]]-[[RsbS]]

* '''Localization:'''

=== Database entries ===

* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2BNL 2BNL] (N-terminal domain), [http://www.rcsb.org/pdb/explore.do?structureId=3VY9 3VY9] (complete stressosome)

* '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/P42409 P42409]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu+BSU04670]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''[[rsbR]]-[[rsbS]]-[[rsbT]]-[[rsbU]]-[[rsbV]]-[[rsbW]]-[[sigB]]-[[rsbX]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/8002610 PubMed]

* '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/8002610 PubMed]

* '''Regulation:'''

* '''Regulatory mechanism:'''

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

* [[Bill Haldenwang]], San Antonio, USA
* [[Chet Price]], Davis, USA [http://foodscience.ucdavis.edu/price_lab/pricelab.html homepage]
* [[Rick Lewis]], Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/r.lewis homepage]

=Your additional remarks=

=References=

<pubmed> 12950928, 15466036, 9179850, 8955331, 18832644 ,17726680 ,17218307 </pubmed>
# Author1, Author2 & Author3 (year) Title ''Journal'' '''volume:''' page-page. [http://www.ncbi.nlm.nih.gov/sites/entrez/PMID PubMed]

RsbR

2009-06-12T12:23:14Z

Janpf: /* Extended information on the protein */

* '''Description:''' activator of RsbT kinase activity, part of the stressosome <br/><br/>

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''rsbR''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ycxR, rsbRA''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || activator of RsbT kinase activity
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || control of SigB activity
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 30 kDa, 4.731
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 822 bp, 274 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ndoA]]'', ''[[rsbS]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB12274]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:rsbR_context.gif]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|}

__TOC__

<br/><br/>

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU04670

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/rsbRSTUVW-sigB-rsbX.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11090]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:'''

* '''Paralogous protein(s):''' [[RsbRB]], [[RsbRC]], [[RsbRD]], [[YtvA]]

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:''' N-terminal nonheme globin domain C-terminal STAS (Sulphate Transporter and AntiSigma factor antagonist) domain

* '''Modification:''' phosphorylation on Thr-186 [http://www.ncbi.nlm.nih.gov/sites/entrez/17218307 PubMed], phosphorylation on Thr-171 [http://www.ncbi.nlm.nih.gov/pubmed/17726680 PubMed]

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:''' [[RsbR]]-[[RsbT]], [[RsbR]]-[[RsbS]]

* '''Localization:'''

=== Database entries ===

* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2BNL 2BNL] (N-terminal domain), [http://www.rcsb.org/pdb/explore.do?structureId=3VY9 3VY9] (complete stressosome)

* '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/P42409 P42409]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu+BSU04670]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''[[rsbR]]-[[rsbS]]-[[rsbT]]-[[rsbU]]-[[rsbV]]-[[rsbW]]-[[sigB]]-[[rsbX]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/8002610 PubMed]

* '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/8002610 PubMed]

* '''Regulation:'''

* '''Regulatory mechanism:'''

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

* [[Bill Haldenwang]], San Antonio, USA
* [[Chet Price]], Davis, USA [http://foodscience.ucdavis.edu/price_lab/pricelab.html homepage]
* [[Rick Lewis]], Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/r.lewis homepage]

=Your additional remarks=

=References=

<pubmed> 12950928, 15466036, 9179850, 8955331, 18832644 ,17726680 ,17218307 </pubmed>
# Author1, Author2 & Author3 (year) Title ''Journal'' '''volume:''' page-page. [http://www.ncbi.nlm.nih.gov/sites/entrez/PMID PubMed]