SubtiWiki - User contributions [en]

ParB

2009-09-11T21:47:02Z

Mberkmen: /* References */

* '''Description:''' chromosome positioning near the pole and transport through the polar septum / antagonist of [[Soj]]-dependent inhibition of sporulation initiation <br/><br/>

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''spo0J''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''spo0JB ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || site-specific DNA-binding protein
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || chromosome positioning before asymmetric septation,

specifying its orientation, and imposing directionality on

its subsequent transport through the septum; required for sporulation

(antagonist of [[Soj]]-dependent inhibition of sporulation initiation)
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 32 kDa, 8.417
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 846 bp, 282 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yyaC]]'', ''[[soj]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB16133]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:spo0J_context.gif]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|}

__TOC__

<br/><br/>

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU40960

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/soj-spo0J.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10054]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:''' parB family (according to Swiss-Prot)

* '''Paralogous protein(s):''' [[Noc]]

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:'''

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P26497 P26497]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU40960]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:'''

* '''[[Sigma factor]]:'''

* '''Regulation:'''
** repressed under conditions that trigger sporulation ([[Spo0A]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]

* '''Regulatory mechanism:'''
** [[Spo0A]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>17462018 16677298 12562803, 10852876, 10482533, 9506522, 8071208, 9663676,11532141,19450516,15659156,18854156,9159397,8866474,9778525,16925562,1900505,9364919,9701805,12950914,,14651647, 19450517, 19450516 </pubmed>

[[Category:Protein-coding genes]]

DnaN

2009-09-11T21:38:01Z

Mberkmen: /* Biological materials */

* '''Description:''' DNA polymerase III (beta subunit), beta clamp <br/><br/>

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''dnaN''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''dnaG, dnaK ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || DNA polymerase III <br/>(beta subunit), beta clamp
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || DNA replication
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 41 kDa, 4.718
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1134 bp, 378 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[dnaA]]'', ''[[yaaA]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB11778]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:DnaA_dnaN_yaaA_recF_yaaB_gyrB_context.png]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|}

__TOC__

<br/><br/><br/>

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU00020

===Phenotypes of a mutant ===

essential [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/dnaAN.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10066]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:''' Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) (according to Swiss-Prot)

* '''Protein family:'''

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:''' [[DnaA]]-[[YabA]]-[[DnaN]] [http://www.ncbi.nlm.nih.gov/sites/entrez/12060778 PubMed]

* '''Localization:''' cytoplasm (according to Swiss-Prot), nucleoid (mid-cell spot) [http://www.ncbi.nlm.nih.gov/sites/entrez/9822387 PubMed] [http://www.ncbi.nlm.nih.gov/sites/entrez/16479537 PubMed]

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P05649 P05649]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU00020]

* '''E.C. number:''' [http://www.expasy.org/enzyme/2.7.7.7 2.7.7.7]

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''[[dnaA]]-[[dnaN]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/2987848 PubMed]

* '''[[Sigma factor]]:''' [[SigG]] {{PubMed|15699190}}, [[SigA]] {{PubMed|2987848}}

* '''Regulation:''' negatively controlled by [[DnaA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/2168872 PubMed] and [[Spo0A]] [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]
** repressed under conditions that trigger sporulation ([[Spo0A]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]

* '''Regulatory mechanism:'''
** [[Spo0A]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:''' [http://www.ncbi.nlm.nih.gov/sites/entrez/16942601 PubMed] [http://www.ncbi.nlm.nih.gov/sites/entrez/9822387 PubMed]

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=
[[Philippe Noirot]], Jouy-en-Josas, France [http://locus.jouy.inra.fr/cms/index.php?id=18 homepage]

=Your additional remarks=

=References=

<pubmed>16942601 9822387 14651647,2987848 2168872 14651647 12060778 16461910, 16479537 19737352 </pubmed>

[[Category:Protein-coding genes]]

DnaN

2009-09-11T21:36:29Z

Mberkmen: /* Biological materials */

* '''Description:''' DNA polymerase III (beta subunit), beta clamp <br/><br/>

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''dnaN''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''dnaG, dnaK ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || DNA polymerase III <br/>(beta subunit), beta clamp
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || DNA replication
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 41 kDa, 4.718
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1134 bp, 378 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[dnaA]]'', ''[[yaaA]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB11778]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:DnaA_dnaN_yaaA_recF_yaaB_gyrB_context.png]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|}

__TOC__

<br/><br/><br/>

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU00020

===Phenotypes of a mutant ===

essential [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/dnaAN.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10066]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:''' Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) (according to Swiss-Prot)

* '''Protein family:'''

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:''' [[DnaA]]-[[YabA]]-[[DnaN]] [http://www.ncbi.nlm.nih.gov/sites/entrez/12060778 PubMed]

* '''Localization:''' cytoplasm (according to Swiss-Prot), nucleoid (mid-cell spot) [http://www.ncbi.nlm.nih.gov/sites/entrez/9822387 PubMed] [http://www.ncbi.nlm.nih.gov/sites/entrez/16479537 PubMed]

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P05649 P05649]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU00020]

* '''E.C. number:''' [http://www.expasy.org/enzyme/2.7.7.7 2.7.7.7]

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''[[dnaA]]-[[dnaN]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/2987848 PubMed]

* '''[[Sigma factor]]:''' [[SigG]] {{PubMed|15699190}}, [[SigA]] {{PubMed|2987848}}

* '''Regulation:''' negatively controlled by [[DnaA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/2168872 PubMed] and [[Spo0A]] [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]
** repressed under conditions that trigger sporulation ([[Spo0A]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]

* '''Regulatory mechanism:'''
** [[Spo0A]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=
[[Philippe Noirot]], Jouy-en-Josas, France [http://locus.jouy.inra.fr/cms/index.php?id=18 homepage]

=Your additional remarks=

=References=

<pubmed>16942601 9822387 14651647,2987848 2168872 14651647 12060778 16461910, 16479537 19737352 </pubmed>

[[Category:Protein-coding genes]]

DnaN

2009-09-11T21:35:45Z

Mberkmen: /* Biological materials */

* '''Description:''' DNA polymerase III (beta subunit), beta clamp <br/><br/>

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''dnaN''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''dnaG, dnaK ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || DNA polymerase III <br/>(beta subunit), beta clamp
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || DNA replication
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 41 kDa, 4.718
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1134 bp, 378 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[dnaA]]'', ''[[yaaA]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB11778]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:DnaA_dnaN_yaaA_recF_yaaB_gyrB_context.png]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|}

__TOC__

<br/><br/><br/>

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU00020

===Phenotypes of a mutant ===

essential [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/dnaAN.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10066]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:''' Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) (according to Swiss-Prot)

* '''Protein family:'''

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:''' [[DnaA]]-[[YabA]]-[[DnaN]] [http://www.ncbi.nlm.nih.gov/sites/entrez/12060778 PubMed]

* '''Localization:''' cytoplasm (according to Swiss-Prot), nucleoid (mid-cell spot) [http://www.ncbi.nlm.nih.gov/sites/entrez/9822387 PubMed] [http://www.ncbi.nlm.nih.gov/sites/entrez/16479537 PubMed]

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P05649 P05649]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU00020]

* '''E.C. number:''' [http://www.expasy.org/enzyme/2.7.7.7 2.7.7.7]

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''[[dnaA]]-[[dnaN]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/2987848 PubMed]

* '''[[Sigma factor]]:''' [[SigG]] {{PubMed|15699190}}, [[SigA]] {{PubMed|2987848}}

* '''Regulation:''' negatively controlled by [[DnaA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/2168872 PubMed] and [[Spo0A]] [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]
** repressed under conditions that trigger sporulation ([[Spo0A]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]

* '''Regulatory mechanism:'''
** [[Spo0A]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:''' <pubmed>16942601 9822387 14651647,2987848 2168872 14651647 12060778 16461910, 16479537 19737352 </pubmed>

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=
[[Philippe Noirot]], Jouy-en-Josas, France [http://locus.jouy.inra.fr/cms/index.php?id=18 homepage]

=Your additional remarks=

=References=

<pubmed>16942601 9822387 14651647,2987848 2168872 14651647 12060778 16461910, 16479537 19737352 </pubmed>

[[Category:Protein-coding genes]]

DnaN

2009-09-11T21:35:13Z

Mberkmen: /* References */

* '''Description:''' DNA polymerase III (beta subunit), beta clamp <br/><br/>

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''dnaN''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''dnaG, dnaK ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || DNA polymerase III <br/>(beta subunit), beta clamp
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || DNA replication
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 41 kDa, 4.718
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1134 bp, 378 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[dnaA]]'', ''[[yaaA]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB11778]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:DnaA_dnaN_yaaA_recF_yaaB_gyrB_context.png]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|}

__TOC__

<br/><br/><br/>

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU00020

===Phenotypes of a mutant ===

essential [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/dnaAN.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10066]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:''' Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) (according to Swiss-Prot)

* '''Protein family:'''

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:''' [[DnaA]]-[[YabA]]-[[DnaN]] [http://www.ncbi.nlm.nih.gov/sites/entrez/12060778 PubMed]

* '''Localization:''' cytoplasm (according to Swiss-Prot), nucleoid (mid-cell spot) [http://www.ncbi.nlm.nih.gov/sites/entrez/9822387 PubMed] [http://www.ncbi.nlm.nih.gov/sites/entrez/16479537 PubMed]

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P05649 P05649]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU00020]

* '''E.C. number:''' [http://www.expasy.org/enzyme/2.7.7.7 2.7.7.7]

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''[[dnaA]]-[[dnaN]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/2987848 PubMed]

* '''[[Sigma factor]]:''' [[SigG]] {{PubMed|15699190}}, [[SigA]] {{PubMed|2987848}}

* '''Regulation:''' negatively controlled by [[DnaA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/2168872 PubMed] and [[Spo0A]] [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]
** repressed under conditions that trigger sporulation ([[Spo0A]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]

* '''Regulatory mechanism:'''
** [[Spo0A]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=
[[Philippe Noirot]], Jouy-en-Josas, France [http://locus.jouy.inra.fr/cms/index.php?id=18 homepage]

=Your additional remarks=

=References=

<pubmed>16942601 9822387 14651647,2987848 2168872 14651647 12060778 16461910, 16479537 19737352 </pubmed>

[[Category:Protein-coding genes]]

DnaN

2009-09-11T21:33:50Z

Mberkmen: /* References */

* '''Description:''' DNA polymerase III (beta subunit), beta clamp <br/><br/>

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''dnaN''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''dnaG, dnaK ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || DNA polymerase III <br/>(beta subunit), beta clamp
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || DNA replication
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 41 kDa, 4.718
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1134 bp, 378 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[dnaA]]'', ''[[yaaA]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB11778]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:DnaA_dnaN_yaaA_recF_yaaB_gyrB_context.png]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|}

__TOC__

<br/><br/><br/>

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU00020

===Phenotypes of a mutant ===

essential [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/dnaAN.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10066]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:''' Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) (according to Swiss-Prot)

* '''Protein family:'''

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:''' [[DnaA]]-[[YabA]]-[[DnaN]] [http://www.ncbi.nlm.nih.gov/sites/entrez/12060778 PubMed]

* '''Localization:''' cytoplasm (according to Swiss-Prot), nucleoid (mid-cell spot) [http://www.ncbi.nlm.nih.gov/sites/entrez/9822387 PubMed] [http://www.ncbi.nlm.nih.gov/sites/entrez/16479537 PubMed]

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P05649 P05649]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU00020]

* '''E.C. number:''' [http://www.expasy.org/enzyme/2.7.7.7 2.7.7.7]

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''[[dnaA]]-[[dnaN]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/2987848 PubMed]

* '''[[Sigma factor]]:''' [[SigG]] {{PubMed|15699190}}, [[SigA]] {{PubMed|2987848}}

* '''Regulation:''' negatively controlled by [[DnaA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/2168872 PubMed] and [[Spo0A]] [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]
** repressed under conditions that trigger sporulation ([[Spo0A]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]

* '''Regulatory mechanism:'''
** [[Spo0A]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=
[[Philippe Noirot]], Jouy-en-Josas, France [http://locus.jouy.inra.fr/cms/index.php?id=18 homepage]

=Your additional remarks=

=References=

<pubmed>9822387 14651647,2987848 2168872 14651647 12060778 16461910, 16479537 19737352 </pubmed>

[[Category:Protein-coding genes]]

DnaN

2009-09-11T21:32:19Z

Mberkmen: /* Extended information on the protein */

* '''Description:''' DNA polymerase III (beta subunit), beta clamp <br/><br/>

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''dnaN''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''dnaG, dnaK ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || DNA polymerase III <br/>(beta subunit), beta clamp
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || DNA replication
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 41 kDa, 4.718
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1134 bp, 378 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[dnaA]]'', ''[[yaaA]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB11778]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:DnaA_dnaN_yaaA_recF_yaaB_gyrB_context.png]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|}

__TOC__

<br/><br/><br/>

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU00020

===Phenotypes of a mutant ===

essential [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/dnaAN.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10066]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:''' Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) (according to Swiss-Prot)

* '''Protein family:'''

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:''' [[DnaA]]-[[YabA]]-[[DnaN]] [http://www.ncbi.nlm.nih.gov/sites/entrez/12060778 PubMed]

* '''Localization:''' cytoplasm (according to Swiss-Prot), nucleoid (mid-cell spot) [http://www.ncbi.nlm.nih.gov/sites/entrez/9822387 PubMed] [http://www.ncbi.nlm.nih.gov/sites/entrez/16479537 PubMed]

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P05649 P05649]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU00020]

* '''E.C. number:''' [http://www.expasy.org/enzyme/2.7.7.7 2.7.7.7]

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''[[dnaA]]-[[dnaN]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/2987848 PubMed]

* '''[[Sigma factor]]:''' [[SigG]] {{PubMed|15699190}}, [[SigA]] {{PubMed|2987848}}

* '''Regulation:''' negatively controlled by [[DnaA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/2168872 PubMed] and [[Spo0A]] [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]
** repressed under conditions that trigger sporulation ([[Spo0A]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]

* '''Regulatory mechanism:'''
** [[Spo0A]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=
[[Philippe Noirot]], Jouy-en-Josas, France [http://locus.jouy.inra.fr/cms/index.php?id=18 homepage]

=Your additional remarks=

=References=

<pubmed>14651647,2987848 2168872 14651647 12060778 16461910, 16479537 19737352 </pubmed>

[[Category:Protein-coding genes]]

DnaA

2009-09-11T21:28:17Z

Mberkmen: /* References */

* '''Description:''' replication initiation protein <br/><br/>

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''dnaA''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''dnaH, dnaJ, dnaK ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || replication initiation protein
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || DNA replication
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 50 kDa, 6.035
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1338 bp, 446 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[rpmH]]'', ''[[dnaN]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB11777]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:DnaA_dnaN_yaaA_recF_yaaB_gyrB_context.png]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|}

__TOC__

<br/><br/>

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU00010

===Phenotypes of a mutant ===

essential [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/dnaAN.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10065]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:''' dnaA family (according to Swiss-Prot)

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:''' [[SirA]] displaces [[DnaA]] from the replication origin {{PubMed|19682252}}

* '''Interactions:''' [[DnaA]]-[[YabA]], [[DnaA]]-[[YabA]]-[[DnaN]] [http://www.ncbi.nlm.nih.gov/sites/entrez/12060778 PubMed], [[DnaA]]-[[DnaD]] [http://www.ncbi.nlm.nih.gov/sites/entrez/11222620 PubMed], [[SirA]]-[[DnaA]] {{PubMed|19682252}}

* '''Localization:''' cytoplasm (according to Swiss-Prot), throughout the cytoplasm [http://www.ncbi.nlm.nih.gov/sites/entrez/10844689 PubMed]

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P05648 P05648]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU00010]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''[[dnaA]]-[[dnaN]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/2987848 PubMed]

* '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/2987848 PubMed]

* '''Regulation:''' negatively controlled by [[DnaA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/2168872 PubMed] and [[Spo0A]] [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]
** repressed under conditions that trigger sporulation ([[Spo0A]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]

* '''Regulatory mechanism:'''
** [[Spo0A]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=
[[Philippe Noirot]], Jouy-en-Josas, France [http://locus.jouy.inra.fr/cms/index.php?id=18 homepage]

[[Peter Graumann]], Freiburg University, Germany [http://www.biologie.uni-freiburg.de/data/bio2/graumann/index.htm homepage]

[[Alan Grossman]], MIT, Cambridge, MA, USA

=Your additional remarks=

=References=

<pubmed>18854156,19011033, 11222620,14651647,17140409 10844689 ,16120674, 11222620 12060778 16461910 2987848 2168872 14651647,11207367, 19682252 19737352 </pubmed>

[[Category:Protein-coding genes]]

DnaA

2009-09-11T21:25:28Z

Mberkmen: /* References */

* '''Description:''' replication initiation protein <br/><br/>

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''dnaA''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''dnaH, dnaJ, dnaK ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || replication initiation protein
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || DNA replication
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 50 kDa, 6.035
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1338 bp, 446 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[rpmH]]'', ''[[dnaN]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB11777]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:DnaA_dnaN_yaaA_recF_yaaB_gyrB_context.png]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|}

__TOC__

<br/><br/>

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU00010

===Phenotypes of a mutant ===

essential [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/dnaAN.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10065]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:''' dnaA family (according to Swiss-Prot)

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:''' [[SirA]] displaces [[DnaA]] from the replication origin {{PubMed|19682252}}

* '''Interactions:''' [[DnaA]]-[[YabA]], [[DnaA]]-[[YabA]]-[[DnaN]] [http://www.ncbi.nlm.nih.gov/sites/entrez/12060778 PubMed], [[DnaA]]-[[DnaD]] [http://www.ncbi.nlm.nih.gov/sites/entrez/11222620 PubMed], [[SirA]]-[[DnaA]] {{PubMed|19682252}}

* '''Localization:''' cytoplasm (according to Swiss-Prot), throughout the cytoplasm [http://www.ncbi.nlm.nih.gov/sites/entrez/10844689 PubMed]

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P05648 P05648]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU00010]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''[[dnaA]]-[[dnaN]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/2987848 PubMed]

* '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/2987848 PubMed]

* '''Regulation:''' negatively controlled by [[DnaA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/2168872 PubMed] and [[Spo0A]] [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]
** repressed under conditions that trigger sporulation ([[Spo0A]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]

* '''Regulatory mechanism:'''
** [[Spo0A]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=
[[Philippe Noirot]], Jouy-en-Josas, France [http://locus.jouy.inra.fr/cms/index.php?id=18 homepage]

[[Peter Graumann]], Freiburg University, Germany [http://www.biologie.uni-freiburg.de/data/bio2/graumann/index.htm homepage]

[[Alan Grossman]], MIT, Cambridge, MA, USA

=Your additional remarks=

=References=

<pubmed>18854156,11222620,14651647,17140409 10844689 11222620 12060778 16461910 2987848 2168872 14651647, 19682252 19737352 </pubmed>

[[Category:Protein-coding genes]]

DnaA

2009-09-11T21:22:38Z

Mberkmen: /* Labs working on this gene/protein */

* '''Description:''' replication initiation protein <br/><br/>

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''dnaA''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''dnaH, dnaJ, dnaK ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || replication initiation protein
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || DNA replication
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 50 kDa, 6.035
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1338 bp, 446 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[rpmH]]'', ''[[dnaN]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB11777]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:DnaA_dnaN_yaaA_recF_yaaB_gyrB_context.png]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|}

__TOC__

<br/><br/>

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU00010

===Phenotypes of a mutant ===

essential [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/dnaAN.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10065]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:''' dnaA family (according to Swiss-Prot)

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:''' [[SirA]] displaces [[DnaA]] from the replication origin {{PubMed|19682252}}

* '''Interactions:''' [[DnaA]]-[[YabA]], [[DnaA]]-[[YabA]]-[[DnaN]] [http://www.ncbi.nlm.nih.gov/sites/entrez/12060778 PubMed], [[DnaA]]-[[DnaD]] [http://www.ncbi.nlm.nih.gov/sites/entrez/11222620 PubMed], [[SirA]]-[[DnaA]] {{PubMed|19682252}}

* '''Localization:''' cytoplasm (according to Swiss-Prot), throughout the cytoplasm [http://www.ncbi.nlm.nih.gov/sites/entrez/10844689 PubMed]

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P05648 P05648]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU00010]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''[[dnaA]]-[[dnaN]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/2987848 PubMed]

* '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/2987848 PubMed]

* '''Regulation:''' negatively controlled by [[DnaA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/2168872 PubMed] and [[Spo0A]] [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]
** repressed under conditions that trigger sporulation ([[Spo0A]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]

* '''Regulatory mechanism:'''
** [[Spo0A]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=
[[Philippe Noirot]], Jouy-en-Josas, France [http://locus.jouy.inra.fr/cms/index.php?id=18 homepage]

[[Peter Graumann]], Freiburg University, Germany [http://www.biologie.uni-freiburg.de/data/bio2/graumann/index.htm homepage]

[[Alan Grossman]], MIT, Cambridge, MA, USA

=Your additional remarks=

=References=

<pubmed>18854156,,11222620,14651647,10844689 11222620 12060778 16461910 2987848 2168872 14651647, 19682252 19737352 </pubmed>

[[Category:Protein-coding genes]]

Melanie Barker Berkmen

2009-09-10T18:48:50Z

Mberkmen: /* Lab head: Melanie Barker Berkmen */

= Lab head: Melanie Barker Berkmen=
'''Additional information'''
* [mailto:mberkmen@suffolk.edu send mail]
* location: Suffolk University, Boston, MA, USA
* Homepage: [http://openwetware.org/wiki/Berkmen Link]

= Publications =
[http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Berkmen%2BMB%22%5Bau%5D&dispmax=50 Pubmed]

= Main research interests =
structure, function, and localization of the ICE''Bs1'' mating machinery

Alan Grossman

2009-09-10T18:47:34Z

Mberkmen: /* Lab head: Alan Grossman */

= Lab head: Alan Grossman=
'''Additional information'''
* [mailto:adg@mit.edu send mail]
* location: MIT, Cambridge, MA, USA
* Homepage: [http://web.mit.edu/biology/www/facultyareas/facresearch/grossman.html Link]

= Publications =
[http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Grossman%2BAD%22%5Bau%5D&dispmax=50 Pubmed]

= Main research interests =
We use a combination of genetic, molecular, physiological, biochemical, cell-biological, and genomic approaches to study how cells of ''Bacillus subtilis'' sense internal and external conditions and control basic cellular processes in response to these conditions. We are interested in defining signals that are sensed and characterizing signal transduction and the regulatory outputs. We are studying mechanisms controlling cell-cell signaling, gene expression, development, DNA replication, chromosome dynamics, and horizontal gene transfer.

YabA

2009-09-10T18:46:25Z

Mberkmen: /* Labs working on this gene/protein */

* '''Description:''' tethers [[DnaA]] to the polymerase-clamp protein [[DnaN]] <br/><br/>

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''yabA''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || negative regulator of replication initiation
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || positioning of [[DnaA]]
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 13 kDa, 6.065
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 357 bp, 119 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yaaT]]'', ''[[yabB]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB11809]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:yabA_context.gif]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|}

__TOC__

<br/><br/>

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU00330

===Phenotypes of a mutant ===

strongly reduced growth rate in minimal medium [http://www.ncbi.nlm.nih.gov/sites/entrez/12060778 PubMed]

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10097]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:''' negative control of replication initiation [http://www.ncbi.nlm.nih.gov/sites/entrez/12060778 PubMed]

* '''Protein family:''' yabA family (according to Swiss-Prot)

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:''' leucine zipper

* '''Modification:'''

* '''Cofactor(s):''' Zn cluster

* '''Effectors of protein activity:'''

* '''Interactions:''' [[DnaA]]-[[YabA]]-[[DnaN]] [http://www.ncbi.nlm.nih.gov/sites/entrez/12060778 PubMed]

* '''Localization:'''

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P37542 P37542]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU00330]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:'''

* '''[[Sigma factor]]:'''

* '''Regulation:'''

* '''Regulatory mechanism:'''

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=
[[Philippe Noirot]], Jouy-en-Josas, France [http://locus.jouy.inra.fr/cms/index.php?id=18 homepage]<br>
[[Alan Grossman]], Cambridge, MA, USA

=Your additional remarks=

=References=

<pubmed> 19578359,,12060778 16461910, 19737352 </pubmed>

[[Category:Protein-coding genes]]

YabA

2009-09-10T18:45:53Z

Mberkmen: /* Labs working on this gene/protein */

* '''Description:''' tethers [[DnaA]] to the polymerase-clamp protein [[DnaN]] <br/><br/>

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''yabA''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || negative regulator of replication initiation
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || positioning of [[DnaA]]
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 13 kDa, 6.065
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 357 bp, 119 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yaaT]]'', ''[[yabB]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB11809]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:yabA_context.gif]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|}

__TOC__

<br/><br/>

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU00330

===Phenotypes of a mutant ===

strongly reduced growth rate in minimal medium [http://www.ncbi.nlm.nih.gov/sites/entrez/12060778 PubMed]

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10097]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:''' negative control of replication initiation [http://www.ncbi.nlm.nih.gov/sites/entrez/12060778 PubMed]

* '''Protein family:''' yabA family (according to Swiss-Prot)

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:''' leucine zipper

* '''Modification:'''

* '''Cofactor(s):''' Zn cluster

* '''Effectors of protein activity:'''

* '''Interactions:''' [[DnaA]]-[[YabA]]-[[DnaN]] [http://www.ncbi.nlm.nih.gov/sites/entrez/12060778 PubMed]

* '''Localization:'''

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P37542 P37542]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU00330]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:'''

* '''[[Sigma factor]]:'''

* '''Regulation:'''

* '''Regulatory mechanism:'''

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=
[[Philippe Noirot]], Jouy-en-Josas, France [http://locus.jouy.inra.fr/cms/index.php?id=18 homepage]
[[Alan Grossman]], Cambridge, MA, USA

=Your additional remarks=

=References=

<pubmed> 19578359,,12060778 16461910, 19737352 </pubmed>

[[Category:Protein-coding genes]]

Alan Grossman

2009-09-10T18:41:57Z

Mberkmen: /* Main research interests */

= Lab head: Alan Grossman=
'''Additional information'''
* [mailto:adg@mit.edu send mail]
* location: Cambridge, MA, USA
* Homepage: [http://web.mit.edu/biology/www/facultyareas/facresearch/grossman.html Link]

= Publications =
[http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Grossman%2BAD%22%5Bau%5D&dispmax=50 Pubmed]

= Main research interests =
We use a combination of genetic, molecular, physiological, biochemical, cell-biological, and genomic approaches to study how cells of ''Bacillus subtilis'' sense internal and external conditions and control basic cellular processes in response to these conditions. We are interested in defining signals that are sensed and characterizing signal transduction and the regulatory outputs. We are studying mechanisms controlling cell-cell signaling, gene expression, development, DNA replication, chromosome dynamics, and horizontal gene transfer.

Alan Grossman

2009-09-10T18:40:28Z

Mberkmen: Created page with '= Lab head: Alan Grossman= '''Additional information''' * [mailto:adg@mit.edu send mail] * location: Cambridge, MA, USA * Homepage: [http://web.mit.edu/biology/www/facultyareas/…'

= Lab head: Alan Grossman=
'''Additional information'''
* [mailto:adg@mit.edu send mail]
* location: Cambridge, MA, USA
* Homepage: [http://web.mit.edu/biology/www/facultyareas/facresearch/grossman.html Link]

= Publications =
[http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Grossman%2BAD%22%5Bau%5D&dispmax=50 Pubmed]

= Main research interests =
We use a combination of genetic, molecular, physiological, biochemical, cell-biological, and genomic approaches to study how cells of Bacillus subtilis sense internal and external conditions and control basic cellular processes in response to these conditions. We are interested in defining signals that are sensed and characterizing signal transduction and the regulatory outputs. We are studying mechanisms controlling cell-cell signaling, gene expression, development, DNA replication, chromosome dynamics, and horizontal gene transfer.

Labs working on Bacillus

2009-09-10T18:37:37Z

Mberkmen:

This is a partial list of groups working with ''Bacillus subtilis'':

* [[Alessandra Albertini]]
* [[Arthur Aronson]]
* [[Stephane Aymerich]]
* [[Imrich Barak]]
* [[David Bechhofer]]
* [[Melanie Barker Berkmen]]
* [[Sabine Brantl]]
* [[Erhard Bremer]]
* [[Richard Brennan]]
* [[Ciaran Condon]]
* [[Simon Cutting]]
* [[Isabel de Sa-Nogueira]]
* [[Nathalie Declerck]]
* [[Kevin Devine]]
* [[Josef Deutscher]]
* [[Jeff Errington]]
* [[Jan Maarten van Dijl]]
* [[Susan Fisher]]
* [[Yasutaro Fujita]]
* [[Anne Galinier]]
* [[Boris Görke]]
* [[Peter Graumann]]
* [[Alan Grossman]]
* [[Bill Haldenwang]]
* [[Leendert Hamoen]]
* [[Elisabeth Härtig]]
* [[Roland Hartmann]]
* [[Colin Harwood]]
* [[Michael Hecker]]
* [[Lars Hederstedt]]
* [[John Helmann]]
* [[Tina Henkin]]
* [[Adriano Henriques]]
* [[Wolfgang Hillen]]
* [[Jim Hoch]]
* [[Marion Hulett]]
* [[Laurent Janniere]]
* [[Hanne Jarmer]]
* [[Mark J. Jedrzejas]]
* [[Daniel Kearns]]
* [[Oscar Kuipers]]
* [[Rick Lewis]]
* [[Isabelle Martin-Verstraete]]
* [[Thorsten Mascher]]
* [[Ivan Mijakovic]]
* [[Anne Moir]]
* [[Charles Moran]]
* [[Michiko Nakano]]
* [[Philippe Noirot]]
* [[Naotake Ogasawara]]
* [[Chet Price]]
* [[Harald Putzer]]
* [[Milton H. Saier]]
* [[Margarita Salas]]
* [[Uwe Sauer]]
* [[Wolfgang Schumann]]
* [[Linc Sonenshein]]
* [[Mark Strauch]]
* [[Jörg Stülke]]
* [[Hendrik Szurmant]]
* [[User:Jwveening |Jan-Willem Veening]]
* [[Uwe Völker]]
* [[Claes von Wachenfeldt]]
* [[Thomas Wiegert]]
* [[Tony Wilkinson]]
* [[Wade Winkler]]
* [[Ken-ichi Yoshida]]
* [[Daniel R. Zeigler]]
* [[Peter Zuber]]

ConE

2009-09-10T16:09:17Z

Mberkmen: /* Phenotypes of a mutant */

* '''Description:''' conjugation protein of the integrative and conjugative element ICEBs1<br/><br/>

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''conE''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yddE ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || conjugation protein
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || conjugative transfer of ICEBs1
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 96 kDa, 5.511
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 2493 bp, 831 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yddD]]'', ''[[yddF]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB12301]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:yddE_context.gif]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|}

__TOC__

<br/><br/>

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU04940

===Phenotypes of a mutant ===
Defective for conjugal transfer of ICE''Bs1''

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG12112]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:''' required for conjugative transfer of ICEBs1, putative ATPase {{PubMed|19734305}}

* '''Protein family:''' HerA/FtsK Superfamily of ATPases including the well-studied proteins FtsK, SpoIIIE, VirB4, and VirD4

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:''' Located at the cell poles, in close association with the membrane

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P96642 P96642]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU04940]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:'''

* '''[[Sigma factor]]:'''

* '''Regulation:'''

* '''Regulatory mechanism:'''

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=
[[Melanie Barker Berkmen]], Suffolk University, Boston, MA

=Your additional remarks=

=References=
<pubmed> 19734305 </pubmed>
[[Category:Protein-coding genes]]

ConE

2009-09-10T16:05:18Z

Mberkmen: /* Extended information on the protein */

* '''Description:''' conjugation protein of the integrative and conjugative element ICEBs1<br/><br/>

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''conE''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yddE ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || conjugation protein
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || conjugative transfer of ICEBs1
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 96 kDa, 5.511
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 2493 bp, 831 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yddD]]'', ''[[yddF]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB12301]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:yddE_context.gif]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|}

__TOC__

<br/><br/>

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU04940

===Phenotypes of a mutant ===
Completely defective for conjugal transfer of ICE''Bs1''

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG12112]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:''' required for conjugative transfer of ICEBs1, putative ATPase {{PubMed|19734305}}

* '''Protein family:''' HerA/FtsK Superfamily of ATPases including the well-studied proteins FtsK, SpoIIIE, VirB4, and VirD4

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:''' Located at the cell poles, in close association with the membrane

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P96642 P96642]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU04940]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:'''

* '''[[Sigma factor]]:'''

* '''Regulation:'''

* '''Regulatory mechanism:'''

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=
Melanie Berkmen, Suffolk University, Boston, MA

=Your additional remarks=

=References=
<pubmed> 19734305 </pubmed>
[[Category:Protein-coding genes]]

ConE

2009-09-10T16:04:24Z

Mberkmen: /* Basic information/ Evolution */

* '''Description:''' conjugation protein of the integrative and conjugative element ICEBs1<br/><br/>

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''conE''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yddE ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || conjugation protein
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || conjugative transfer of ICEBs1
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 96 kDa, 5.511
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 2493 bp, 831 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yddD]]'', ''[[yddF]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB12301]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:yddE_context.gif]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|}

__TOC__

<br/><br/>

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU04940

===Phenotypes of a mutant ===
Completely defective for conjugal transfer of ICE''Bs1''

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG12112]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:''' required for conjugative transfer of ICEBs1, putative ATPase {{PubMed|19734305}}

* '''Protein family:''' HerA/FtsK Superfamily of ATPases including the well-studied proteins FtsK, SpoIIIE, VirB4, and VirD4

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:'''

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P96642 P96642]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU04940]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:'''

* '''[[Sigma factor]]:'''

* '''Regulation:'''

* '''Regulatory mechanism:'''

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=
Melanie Berkmen, Suffolk University, Boston, MA

=Your additional remarks=

=References=
<pubmed> 19734305 </pubmed>
[[Category:Protein-coding genes]]

ConE

2009-09-10T16:02:45Z

Mberkmen: /* Phenotypes of a mutant */

* '''Description:''' conjugation protein of the integrative and conjugative element ICEBs1<br/><br/>

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''conE''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yddE ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || conjugation protein
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || conjugative transfer of ICEBs1
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 96 kDa, 5.511
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 2493 bp, 831 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yddD]]'', ''[[yddF]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB12301]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:yddE_context.gif]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|}

__TOC__

<br/><br/>

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU04940

===Phenotypes of a mutant ===
Completely defective for conjugal transfer of ICE''Bs1''

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG12112]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:''' involved in conjugative transfer of ICEBs1 {{PubMed|19734305}}

* '''Protein family:'''

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:'''

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P96642 P96642]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU04940]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:'''

* '''[[Sigma factor]]:'''

* '''Regulation:'''

* '''Regulatory mechanism:'''

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=
Melanie Berkmen, Suffolk University, Boston, MA

=Your additional remarks=

=References=
<pubmed> 19734305 </pubmed>
[[Category:Protein-coding genes]]

ConE

2009-09-10T16:01:09Z

Mberkmen: /* Labs working on this gene/protein */

* '''Description:''' conjugation protein of the integrative and conjugative element ICEBs1<br/><br/>

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''conE''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yddE ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || conjugation protein
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || conjugative transfer of ICEBs1
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 96 kDa, 5.511
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 2493 bp, 831 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yddD]]'', ''[[yddF]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB12301]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:yddE_context.gif]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|}

__TOC__

<br/><br/>

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU04940

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG12112]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:''' involved in conjugative transfer of ICEBs1 {{PubMed|19734305}}

* '''Protein family:'''

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:'''

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P96642 P96642]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU04940]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:'''

* '''[[Sigma factor]]:'''

* '''Regulation:'''

* '''Regulatory mechanism:'''

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=
Melanie Berkmen, Suffolk University, Boston, MA

=Your additional remarks=

=References=
<pubmed> 19734305 </pubmed>
[[Category:Protein-coding genes]]

Melanie Barker Berkmen

2009-09-10T15:58:45Z

Mberkmen: /* Main research interests */

= Lab head: Melanie Barker Berkmen=
'''Additional information'''
* [mailto:mberkmen@suffolk.edu send mail]
* location: Boston, MA, USA
* Homepage: [http://openwetware.org/wiki/Berkmen]

= Publications =
[http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Berkmen%2BMB%22%5Bau%5D&dispmax=50 Pubmed]

= Main research interests =
structure, function, and localization of the ICE''Bs1'' mating machinery

Melanie Barker Berkmen

2009-09-10T15:58:20Z

Mberkmen: /* Publications */

Melanie Barker Berkmen

2009-09-10T15:57:03Z

Mberkmen: /* Lab head: Melanie Barker Berkmen */

= Lab head: Melanie Barker Berkmen=
'''Additional information'''
* [mailto:mberkmen@suffolk.edu send mail]
* location: Boston, MA, USA
* Homepage: [http://openwetware.org/wiki/Berkmen]

= Publications =
[http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Berkmen MB%5D&dispmax=50 Pubmed]

= Main research interests =
structure, function, and localization of the ICEBs1 mating machinery

Melanie Barker Berkmen

2009-09-10T15:55:35Z

Mberkmen: /* Publications */

= Lab head: Melanie Barker Berkmen=
'''Additional information'''
* [mailto:mberkmen@suffolk.edu]
* location: Boston, MA, USA
* Homepage: [http://openwetware.org/wiki/Berkmen]

= Publications =
[http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Berkmen MB%5D&dispmax=50 Pubmed]

= Main research interests =
structure, function, and localization of the ICEBs1 mating machinery

Melanie Barker Berkmen

2009-09-10T15:55:09Z

Mberkmen: /* Publications */

= Lab head: Melanie Barker Berkmen=
'''Additional information'''
* [mailto:mberkmen@suffolk.edu]
* location: Boston, MA, USA
* Homepage: [http://openwetware.org/wiki/Berkmen]

= Publications =
[http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Berkmen%2MB%5D&dispmax=50 Pubmed]

= Main research interests =
structure, function, and localization of the ICEBs1 mating machinery

Melanie Barker Berkmen

2009-09-10T15:54:21Z

Mberkmen:

= Lab head: Melanie Barker Berkmen=
'''Additional information'''
* [mailto:mberkmen@suffolk.edu]
* location: Boston, MA, USA
* Homepage: [http://openwetware.org/wiki/Berkmen]

= Publications =
[http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Berkmen%2MB%22%5Bau%5D&dispmax=50 Pubmed]

= Main research interests =
structure, function, and localization of the ICEBs1 mating machinery

Melanie Barker Berkmen

2009-09-10T15:52:59Z

Mberkmen: Created page with '= Lab head: Melanie Barker Berkmen= '''Additional information''' * [mailto:mberkmen@suffolk.edu] * location: Boston, MA, USA * Homepage: [http://http://openwetware.org/wiki/Berk…'

= Lab head: Melanie Barker Berkmen=
'''Additional information'''
* [mailto:mberkmen@suffolk.edu]
* location: Boston, MA, USA
* Homepage: [http://http://openwetware.org/wiki/Berkmen]

= Publications =
[http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Berkmen%2MB%22%5Bau%5D&dispmax=50 Pubmed]

= Main research interests =
structure, function, and localization of the ICEBs1 mating machinery

Labs working on Bacillus

2009-09-10T15:48:04Z

Mberkmen:

This is a partial list of groups working with ''Bacillus subtilis'':

* [[Alessandra Albertini]]
* [[Arthur Aronson]]
* [[Stephane Aymerich]]
* [[Imrich Barak]]
* [[David Bechhofer]]
* [[Melanie Barker Berkmen]]
* [[Sabine Brantl]]
* [[Erhard Bremer]]
* [[Richard Brennan]]
* [[Ciaran Condon]]
* [[Simon Cutting]]
* [[Isabel de Sa-Nogueira]]
* [[Nathalie Declerck]]
* [[Kevin Devine]]
* [[Josef Deutscher]]
* [[Jeff Errington]]
* [[Jan Maarten van Dijl]]
* [[Susan Fisher]]
* [[Yasutaro Fujita]]
* [[Anne Galinier]]
* [[Boris Görke]]
* [[Peter Graumann]]
* [[Bill Haldenwang]]
* [[Leendert Hamoen]]
* [[Elisabeth Härtig]]
* [[Roland Hartmann]]
* [[Colin Harwood]]
* [[Michael Hecker]]
* [[Lars Hederstedt]]
* [[John Helmann]]
* [[Tina Henkin]]
* [[Adriano Henriques]]
* [[Wolfgang Hillen]]
* [[Jim Hoch]]
* [[Marion Hulett]]
* [[Laurent Janniere]]
* [[Hanne Jarmer]]
* [[Mark J. Jedrzejas]]
* [[Daniel Kearns]]
* [[Oscar Kuipers]]
* [[Rick Lewis]]
* [[Isabelle Martin-Verstraete]]
* [[Thorsten Mascher]]
* [[Ivan Mijakovic]]
* [[Anne Moir]]
* [[Charles Moran]]
* [[Michiko Nakano]]
* [[Philippe Noirot]]
* [[Naotake Ogasawara]]
* [[Chet Price]]
* [[Harald Putzer]]
* [[Milton H. Saier]]
* [[Margarita Salas]]
* [[Uwe Sauer]]
* [[Wolfgang Schumann]]
* [[Linc Sonenshein]]
* [[Mark Strauch]]
* [[Jörg Stülke]]
* [[Hendrik Szurmant]]
* [[User:Jwveening |Jan-Willem Veening]]
* [[Uwe Völker]]
* [[Claes von Wachenfeldt]]
* [[Thomas Wiegert]]
* [[Tony Wilkinson]]
* [[Wade Winkler]]
* [[Ken-ichi Yoshida]]
* [[Daniel R. Zeigler]]
* [[Peter Zuber]]