SubtiWiki - User contributions [en]

SubtiPathways

2011-03-16T16:17:06Z

Pballin:

[[File:Pathway_start_page_small.png|right|link=http://subtipathways.uni-goettingen.de/]]
[[File:Legende.jpg|250px|thumb|right|'''legend for ''Subti''Pathways graphical notation: click to enlarge''']]

<big>'''''Subti''Pathways''' is a model of '''''B. subtilis''''' metabolism and regulation in '''SBML/SBGN''' (Systems Biology Markup Language/ Graphical Notation). There is a color code for key metabolites (see the legend on the right side). It can be used like Google Maps (scroll and zoom to the pathways). The markers of proteins and compounds listed on the right side in each pathway are containing links to the corresponding ''Subti''Wiki and PubChem pages, respectively. There is a short description for each protein in the bubbles, too.</big>

<big>'''Contact:'''</big> [http://wwwuser.gwdg.de/~genmibio/stuelke.html General Microbiology, University of Göttingen], [mailto:jstuelk@gwdg.de send mail]

<big>'''A publication describing ''Subti''Wiki and ''Subti''Pathways:'''</big>
<pubmed>19959575 </pubmed>
__NOTOC__

 

== A collection of important papers on ''B. subtilis'' [[metabolism]] can be found [[metabolism|here]] ==
 
== Carbon metabolism ==

=== [http://subtiwiki.uni-goettingen.de/pathways/carbon_flow.html Central carbon metabolism] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/carbohydrate_metabolic_pathways.html Utilization of different carbon sources] ===

 

== Nitrogen and amino acid metabolism ==

=== [http://subtiwiki.uni-goettingen.de/pathways/glutamate.html Ammonium assimilation and glutamate metabolism (incl. glutamine and arginine)] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/ala_gly_ser.html Alanine, glycine, serine] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/aspartate_asparagine.html Aspartate, asparagine] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/cys_meth_and_sulfate_assimilation.html Cysteine, methionine] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/histidine.html Histidine] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/ile_val_leu.html Isoleucine, valine, leucine] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/lys_threo.html Lysine, threonine] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/phenyl_tyr_tryp.html Phenylalanine, tyrosine, tryptophan] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/proline.html Proline] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/other_nitrogen_sources/index.html Utilization of other nitrogen sources] ===

 

== Lipid metabolism ==

=== [http://subtiwiki.uni-goettingen.de/pathways/fatty_acid_synthesis.html Fatty acid and phospholipid biosynthesis] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/fatty_acid_degradation.html Fatty acid degradation] ===

 

== Nucleotides ==

=== [http://subtiwiki.uni-goettingen.de/pathways/gene_regulation_nucleotides.html Gene regulation of nucleotide metabolism] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/nucleosides_catabolism.html Nucleoside catabolism] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/purine_biosynthesis.html Purine biosynthesis] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/purines_catabolism.html Purine catabolism] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/purines_salvage_pathways.html Purine salvage pathways] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/pyrimidines_metabolism.html Pyrimidine metabolism] ===

 
== Metabolism of cofactors ==

=== [http://subtiwiki.uni-goettingen.de/pathways/CoA_synthesis.html CoA synthesis] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/folate_biosynthesis.html Folate biosynthesis] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/menaquinone.html Menaquinone] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/riboflavin.html Riboflavin and FAD synthesis] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/thiamin.html Thiamin synthesis] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/biotin/index.html Biotin synthesis] ===

 

== Other pathways ==

=== [http://subtiwiki.uni-goettingen.de/pathways/cellwall.html Cell wall] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/murein/index.html Murein recycling] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress responses] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/phosphorelay.html Phosphorelay] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/cys_meth_and_sulfate_assimilation.html Sulfate assimilation] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/tRNA_charging.html tRNA charging] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/biofilm.html Biofilm formation] ===

=== [http://subtiwiki.uni-goettingen.de/pathways/secretion/index.html Protein secretion] ===

=== [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis] ===

KtrD

2011-03-10T23:03:11Z

Pballin:

* '''Description:''' low affinity potassium transporter [[KtrC]]-[[KtrD]], integral membrane subunit 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''ktrD ''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ykrM''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || low affinity potassium transporter [[KtrC]]-[[KtrD]], integral membrane subunit (proton symport)
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || potassium uptake
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 49 kDa, 9.224
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1347 bp, 449 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ykrL]]'', ''[[ykzE]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB13223]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' [[Image:ykrM_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[transporters/ other]]}},
{{SubtiWiki category|[[metal ion homeostasis (K, Na, Ca, Mg)]]}},
{{SubtiWiki category|[[coping with hyper-osmotic stress]]}},
{{SubtiWiki category|[[membrane proteins]]}}

= This gene is a member of the following [[regulons]] =

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU13500

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13275]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:''' View classification (according to Swiss-Prot)

* '''Paralogous protein(s):''' [[KtrB]]

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:''' [[KtrC]]-[[KtrD]] [http://www.ncbi.nlm.nih.gov/sites/entrez/12562800 PubMed]

* '''Localization:''' cell membrane (according to Swiss-Prot), integral membrane protein [http://www.ncbi.nlm.nih.gov/sites/entrez/12562800 PubMed]

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/O31658 O31658]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU13500]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''ktrD'' [http://www.ncbi.nlm.nih.gov/sites/entrez/12562800 PubMed]

* '''[[Sigma factor]]:'''

* '''Regulation:''' constitutively expressed

* '''Regulatory mechanism:'''

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

[[Erhard Bremer]], University of Marburg, Germany [http://www.uni-marburg.de/fb17/fachgebiete/mikrobio/molmibi homepage]

=Your additional remarks=

=References=

<pubmed>12562800,, </pubmed>

[[Category:Protein-coding genes]]

KtrC

2011-03-10T23:00:54Z

Pballin:

* '''Description:''' low affinity potassium transporter [[KtrC]]-[[KtrD]], peripheric membrane component 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''ktrC ''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ylxV, yzaC, ykqB ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || low affinity potassium transporter [[KtrC]]-[[KtrD]], peripheric membrane component (proton symport)
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || potassium uptake
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 24 kDa, 5.63
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 663 bp, 221 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ykqA]]'', ''[[adeC]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB13324]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' [[Image:ykqB_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[transporters/ other]]}},
{{SubtiWiki category|[[metal ion homeostasis (K, Na, Ca, Mg)]]}},
{{SubtiWiki category|[[coping with hyper-osmotic stress]]}},
{{SubtiWiki category|[[membrane proteins]]}}

= This gene is a member of the following [[regulons]] =

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU14510

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10991]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:''' RCK N-terminal domain (according to Swiss-Prot)

* '''Paralogous protein(s):''' [[KtrA]]

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:''' [[KtrC]]-[[KtrD]] [http://www.ncbi.nlm.nih.gov/sites/entrez/12562800 PubMed]

* '''Localization:''' cell membrane (according to Swiss-Prot), peripheral membrane protein [http://www.ncbi.nlm.nih.gov/sites/entrez/12562800 PubMed]

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P39760 P39760]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU14510]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''ktrC'' {{PubMed|12562800}}

* '''[[Sigma factor]]:'''

* '''Regulation:''' constitutively expressed {{PubMed|12562800}}

* '''Regulatory mechanism:'''

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

[[Erhard Bremer]], University of Marburg, Germany [http://www.uni-marburg.de/fb17/fachgebiete/mikrobio/molmibi homepage]

=Your additional remarks=

=References=

<pubmed>12562800,, </pubmed>

[[Category:Protein-coding genes]]

KtrB

2011-03-10T22:57:50Z

Pballin:

* '''Description:''' high affinity potassium transporter [[KtrA]]-[[KtrB]], integral membrane subunit 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''ktrB''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yubG''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || high affinity potassium transporter [[KtrA]]-[[KtrB]], integral membrane subunit (proton symport)
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || potassium uptake
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 48 kDa, 10.116
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1335 bp, 445 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ktrA]]'', ''[[yubF]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB15088]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' [[Image:yubG_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[transporters/ other]]}},
{{SubtiWiki category|[[metal ion homeostasis (K, Na, Ca, Mg)]]}},
{{SubtiWiki category|[[coping with hyper-osmotic stress]]}},
{{SubtiWiki category|[[membrane proteins]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[YdaO riboswitch]]}}

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU31100

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13956]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:'''

* '''Paralogous protein(s):''' [[KtrD]]

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''
** KtrB forms dimers {{PubMed|17932047}}
** [[KtrA]]-[[KtrB]] [http://www.ncbi.nlm.nih.gov/sites/entrez/12562800 PubMed]

* '''Localization:''' cell membrane (according to Swiss-Prot), integral membrane protein [http://www.ncbi.nlm.nih.gov/sites/entrez/12562800 PubMed]

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/O32081 O32081]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU31100]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''[[ktrA]]-[[ktrB]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/12562800 PubMed]

* '''[[Sigma factor]]:'''

* '''Regulation:'''

* '''Regulatory mechanism:'''
** expression is controlled via termination antitermination by the [[ydaO riboswitch]] {{PubMed|20511502}}

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

[[Erhard Bremer]], University of Marburg, Germany [http://www.uni-marburg.de/fb17/fachgebiete/mikrobio/molmibi homepage]

=Your additional remarks=

=References=

<pubmed>12562800,20511502, 17932047 </pubmed>

[[Category:Protein-coding genes]]

KtrA

2011-03-10T22:52:43Z

Pballin:

* '''Description:''' high affinity potassium transporter [[KtrA]]-[[KtrB]], peripheric membrane component (proton symport) 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''ktrA''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yuaA''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || high affinity potassium transporter [[KtrA]]-[[KtrB]], peripheric membrane component (proton symport)
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || potassium uptake
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 24 kDa, 5.981
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 666 bp, 222 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yuaB]]'', ''[[ktrB]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB15087]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' [[Image:yuaA_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[transporters/ other]]}},
{{SubtiWiki category|[[metal ion homeostasis (K, Na, Ca, Mg)]]}},
{{SubtiWiki category|[[coping with hyper-osmotic stress]]}},
{{SubtiWiki category|[[membrane proteins]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[YdaO riboswitch]]}}

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU31090

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13943]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:'''

* '''Paralogous protein(s):''' [[KtrC]]

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:''' [[KtrA]]-[[KtrB]] [http://www.ncbi.nlm.nih.gov/sites/entrez/12562800 PubMed]

* '''Localization:''' cell membrane (according to Swiss-Prot), peripheral membrane protein [http://www.ncbi.nlm.nih.gov/sites/entrez/12562800 PubMed]

=== Database entries ===

* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=1LSU 1LSU] (complex with NADH), [http://www.proteopedia.org/wiki/index.php/2hmw 2HMW] ( complex with ATP)

* '''UniProt:''' [http://www.uniprot.org/uniprot/O32080 O32080]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU31090]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''[[ktrA]]-[[ktrB]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/12562800 PubMed]

* '''[[Sigma factor]]:'''

* '''Regulation:'''

* '''Regulatory mechanism:'''
** expression is controlled via termination antitermination by the [[ydaO riboswitch]] {{PubMed|20511502}}

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

[[Erhard Bremer]], University of Marburg, Germany [http://www.uni-marburg.de/fb17/fachgebiete/mikrobio/molmibi homepage]

=Your additional remarks=

=References=

<pubmed>12562800,15096624, 20511502, </pubmed>

[[Category:Protein-coding genes]]

Fur

2011-03-10T22:48:20Z

Pballin:

* '''Description:''' transcription regulator of iron homoeostasis 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''fur''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yqkL ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || transcriptional repressor
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of iron homoeostasis
and transcription of ferri-siderophore uptake genes
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://subtiwiki.uni-goettingen.de/pathways/other_nitrogen_sources/index.html Alternative nitrogen sources], [http://subtiwiki.uni-goettingen.de/wiki/index.php/Protein_secretion Protein secretion]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 17 kDa, 5.374
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 447 bp, 149 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ripX]]'', ''[[spoIIM]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB14284]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|-
|-
|colspan="2" | '''Genetic context''' [[Image:fur_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[acquisition of iron]]}},
{{SubtiWiki category|[[iron metabolism]]}},
{{SubtiWiki category|[[transcription factors and their control]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[PerR regulon]]}}
=The [[Fur regulon]]=
=The gene=

=== Basic information ===

* '''Locus tag:''' BSU23520

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/fur.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11766]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:''' Fur family (according to Swiss-Prot)

* '''Paralogous protein(s):''' [[PerR]], [[Zur]]

=== Genes controlled by Fur ===

''[[fsrA]]''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):''' contains an iron-sulfur cluster

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:''' cytoplasm (according to Swiss-Prot)

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P54574 P54574]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU23520]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''fur'' {{PubMed|12029044}}

* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|12029044}}

* '''Regulation:'''
** repressed in the absence of hydrogen peroxide ([[PerR]]) {{PubMed|12029044}}

* '''Regulatory mechanism:'''
** [[PerR]]: transcription repression {{PubMed|12029044}}

* '''Additional information:'''

=Biological materials =

* '''Mutant:''' HB6543 (aphA3), available in the [[John Helmann]] lab; also available in the [[Stülke]] lab GP879 (''fur::mls'') and GP868 (''fur::mls'', ''perR::spc'')

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=
[[John Helmann]], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]

=Your additional remarks=

=References=
==The [[Fur regulon]]==
<pubmed>12374814,12354229, </pubmed>
==Other original publications==
<pubmed>18487332,14563870,18697947,10400588,11790741,16672620,12207695,9701813,12029044,,17725565,17012385,12950915,19508286 , 16672620, </pubmed>

[http://www.ncbi.nlm.nih.gov/sites/entrez/PMID PubMed]

[[Category:Protein-coding genes]]

Fur

2011-03-10T22:43:44Z

Pballin:

* '''Description:''' transcription regulator of iron homoeostasis 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''fur''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yqkL ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || transcriptional repressor
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of iron homoeostasis
and transcription of ferri-siderophore uptake genes
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://subtiwiki.uni-goettingen.de/pathways/other_nitrogen_sources/index.html Alternative nitrogen sources], [http://subtiwiki.uni-goettingen.de/wiki/index.php/Protein_secretion Protein secretion]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 17 kDa, 5.374
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 447 bp, 149 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ripX]]'', ''[[spoIIM]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB14284]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|-
|-
|colspan="2" | '''Genetic context''' [[Image:fur_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[acquisition of iron]]}},
{{SubtiWiki category|[[iron metabolism]]}},
{{SubtiWiki category|[[transcription factors and their control]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[PerR regulon]]}}
=The [[Fur regulon]]=
=The gene=

=== Basic information ===

* '''Locus tag:''' BSU23520

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/fur.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11766]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:''' Fur family (according to Swiss-Prot)

* '''Paralogous protein(s):''' [[PerR]], [[Zur]]

=== Genes controlled by Fur ===

''[[fsrA]]''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):''' contains an iron-sulfur cluster

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:''' cytoplasm (according to Swiss-Prot)

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P54574 P54574]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU23520]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''fur'' {{PubMed|12029044}}

* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|12029044}}

* '''Regulation:'''
** repressed in the absence of hydrogen peroxide ([[PerR]]) {{PubMed|12029044}}

* '''Regulatory mechanism:'''
** [[PerR]]: transcription repression {{PubMed|12029044}}

* '''Additional information:'''

=Biological materials =

* '''Mutant:''' HB6543 (aphA3), available in the [[John Helmann]] lab; also available in the [[Stülke]] lab GP879 (''fur::mls'') and GP868 (''fur::mls'', ''perR::spc'')

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=
[[John Helmann]], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]

=Your additional remarks=

=References=
==The [[Fur regulon]]==
<pubmed>12374814,12354229, </pubmed>
==Other original publications==
<pubmed>18487332,14563870,18697947,10400588,11790741,16672620,12207695,9701813,12029044,,17725565,17012385,12950915,19508286 , 16672620, </pubmed>

[http://www.ncbi.nlm.nih.gov/sites/entrez/PMID PubMed]

[[Category:Protein-coding genes]]

FhuG

2011-03-10T22:38:24Z

Pballin:

* '''Description:''' hydroxamate siderophore [[ABC transporter]] (ferrichrome und ferrioxamine) (permease) 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''fhuG''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || hydroxamate siderophore [[ABC transporter]] (ferrichrome und ferrioxamine) (permease)
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || siderophore uptake
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 36 kDa, 10.201
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1008 bp, 336 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[fhuC]]'', ''[[fhuB]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB15336]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' [[Image:fhuG_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[ABC transporters]]}},
{{SubtiWiki category|[[acquisition of iron]]}},
{{SubtiWiki category|[[iron metabolism]]}},
{{SubtiWiki category|[[membrane proteins]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[Fur regulon]]}}

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU33300

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11391]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:''' FecCD subfamily (according to Swiss-Prot)

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:''' [[FhuC]]-([[FhuB]]-[[FhuG]])-([[FhuD]]-[[YxeB]]) {{PubMed|10092453}}

* '''Localization:''' cell membrane (according to Swiss-Prot)

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P49937 P49937]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU33300]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:'''

* '''[[Sigma factor]]:'''

* '''Regulation:'''
** induced upon iron starvation ([[Fur]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]

* '''Regulatory mechanism:'''
** [[Fur]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>10092453,16672620,,12354229, </pubmed>

[[Category:Protein-coding genes]]

FhuD

2011-03-10T22:35:57Z

Pballin:

* '''Description:''' hydroxamate siderophore [[ABC transporter]] (only ferrichrome) (binding protein) 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''fhuD''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || hydroxamate siderophore [[ABC transporter]] (only ferrichrome) (binding protein)
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || siderophore uptake
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 34 kDa, 9.158
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 945 bp, 315 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[fhuB]]'', ''[[yvsH]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB15338]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' [[Image:fhuD_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[ABC transporters]]}},
{{SubtiWiki category|[[acquisition of iron]]}},
{{SubtiWiki category|[[iron metabolism]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[Fur regulon]]}}

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU33320

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/fhuD.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10828]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:''' bacterial solute-binding protein 8 family (according to Swiss-Prot)

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:''' [[FhuC]]-([[FhuB]]-[[FhuG]])-([[FhuD]]-[[YxeB]]) {{PubMed|10092453}}

* '''Localization:''' cell membrane (according to Swiss-Prot), extracellular (signal peptide) [http://www.ncbi.nlm.nih.gov/pubmed/18957862 PubMed]

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P37580 P37580]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU33320]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''fhuD'' (according to [http://dbtbs.hgc.jp/COG/prom/fhuD.html DBTBS])

* '''[[Sigma factor]]:'''

* '''Regulation:'''
** induced upon iron starvation ([[Fur]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]

* '''Regulatory mechanism:'''
** [[Fur]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>10092453,16672620,,12354229,18957862, </pubmed>

[[Category:Protein-coding genes]]

FhuC

2011-03-10T22:33:43Z

Pballin:

* '''Description:''' hydroxamate siderophore [[ABC transporter]] (ATP-binding protein) (ferrichrome und ferrioxamine) 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''fhuC''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || hydroxamate siderophore [[ABC transporter]] (ATP-binding protein) (ferrichrome und ferrioxamine)
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || siderophore uptake
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 6.499
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 807 bp, 269 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yvrP]]'', ''[[fhuG]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB15335]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' [[Image:fhuC_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[ABC transporters]]}},
{{SubtiWiki category|[[acquisition of iron]]}},
{{SubtiWiki category|[[iron metabolism]]}},
{{SubtiWiki category|[[membrane proteins]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[Fur regulon]]}}

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU33290

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11390]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:''' ATP + H2O + iron chelate(Out) = ADP + phosphate + iron chelate(In) (according to Swiss-Prot)

* '''Protein family:'''

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:''' [[FhuC]]-([[FhuB]]-[[FhuG]])-([[FhuD]]-[[YxeB]]) {{PubMed|10092453}}

* '''Localization:''' cell membrane (according to Swiss-Prot)

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P49938 P49938]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU33290]

* '''E.C. number:''' [http://www.expasy.org/enzyme/3.6.3.34 3.6.3.34]

=== Additional information===

=Expression and regulation=

* '''Operon:'''

* '''[[Sigma factor]]:'''

* '''Regulation:'''
** induced upon iron starvation ([[Fur]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]

* '''Regulatory mechanism:'''
** [[Fur]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>10092453,16672620,,12354229, </pubmed>

[[Category:Protein-coding genes]]

FhuB

2011-03-10T22:27:32Z

Pballin:

* '''Description:''' hydroxamate siderophore [[ABC transporter]] (ferrichrome und ferrioxamine) (permease) 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''fhuB''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || hydroxamate siderophore [[ABC transporter]] (ferrichrome und ferrioxamine) (permease)
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || siderophore uptake
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 40 kDa, 10.142
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1152 bp, 384 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[fhuG]]'', ''[[fhuD]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB15337]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' [[Image:fhuB_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[ABC transporters]]}},
{{SubtiWiki category|[[acquisition of iron]]}},
{{SubtiWiki category|[[iron metabolism]]}},
{{SubtiWiki category|[[membrane proteins]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[Fur regulon]]}}

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU33310

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11389]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:''' FecCD subfamily (according to Swiss-Prot)

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:''' [[FhuC]]-([[FhuB]]-[[FhuG]])-([[FhuD]]-[[YxeB]]) {{PubMed|10092453}}

* '''Localization:''' cell membrane (according to Swiss-Prot)

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P49936 P49936]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU33310]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:'''

* '''[[Sigma factor]]:'''

* '''Regulation:'''
** induced upon iron starvation ([[Fur]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]

* '''Regulatory mechanism:'''
** [[Fur]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>10092453,16672620,,12354229, </pubmed>

[[Category:Protein-coding genes]]

FeuC

2011-03-10T22:20:10Z

Pballin:

* '''Description:''' [[ABC transporter]] for the siderophores Fe-enterobactin and Fe-bacillibactin (integral membrane protein) 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''feuC''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || [[ABC transporter]] for the siderophores Fe-enterobactin and Fe-bacillibactin (integral membrane protein)
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || iron acquisition
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 42 kDa, 10.435
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1182 bp, 394 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ybbA]]'', ''[[feuB]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB11937]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' [[Image:feuC_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[ABC transporters]]}},
{{SubtiWiki category|[[acquisition of iron]]}},
{{SubtiWiki category|[[iron metabolism]]}},
{{SubtiWiki category|[[membrane proteins]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[Btr regulon]]}},
{{SubtiWiki regulon|[[CitB regulon]]}},
{{SubtiWiki regulon|[[Fur regulon]]}}

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU01610

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/feuABC-ybbA.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10837]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:''' FecCD subfamily (according to Swiss-Prot)

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:''' [[YusV]]-([[FeuB]]-[[FeuC]])-[[FeuA]] {{PubMed|10092453}}

* '''Localization:''' cell membrane {{PubMed|10092453}}

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P40411 P40411]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU01610]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''[[feuA]]-[[feuB]]-[[feuC]]-[[ybbA]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]

* '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed]

* '''Regulation:'''
** repressed in the presence of iron ([[Fur]], [[CitB]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]
** induced in the presence of iron chelators bacillibactin or enterobactin ([[Btr]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed]

* '''Regulatory mechanism:'''
** [[Fur]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]
** [[CitB]]: binding to the iron responsive element in the absence of iron
** [[Btr]]: transcription activation in the presence of the co-activators bacillibactin or enterobactin [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed]

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>19746494,16672620,10092453,16889643,17725565,,12354229, </pubmed>

[[Category:Protein-coding genes]]

FeuB

2011-03-10T22:17:12Z

Pballin:

* '''Description:''' [[ABC transporter]] for the siderophores Fe-enterobactin and Fe-bacillibactin (integral membrane protein) 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''feuB''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || [[ABC transporter]] for the siderophores Fe-enterobactin and Fe-bacillibactin (integral membrane protein)
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || iron acquisition
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 35 kDa, 9.539
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1002 bp, 334 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[feuC]]'', ''[[feuA]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB11938]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' [[Image:feuB_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[ABC transporters]]}},
{{SubtiWiki category|[[acquisition of iron]]}},
{{SubtiWiki category|[[iron metabolism]]}},
{{SubtiWiki category|[[membrane proteins]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[Btr regulon]]}},
{{SubtiWiki regulon|[[CitB regulon]]}},
{{SubtiWiki regulon|[[Fur regulon]]}}

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU01620

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/feuABC-ybbA.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10836]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:''' FecCD subfamily (according to Swiss-Prot)

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:''' [[YusV]]-([[FeuB]]-[[FeuC]])-[[FeuA]] {{PubMed|10092453}}

* '''Localization:''' cell membrane {{PubMed|10092453}}

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P40410 P40410]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU01620]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''[[feuA]]-[[feuB]]-[[feuC]]-[[ybbA]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]

* '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed]

* '''Regulation:'''
** repressed in the presence of iron ([[Fur]], [[CitB]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]
** induced in the presence of iron chelators bacillibactin or enterobactin ([[Btr]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed]

* '''Regulatory mechanism:'''
** [[Fur]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]
** [[CitB]]: binding to the iron responsive element in the absence of iron
** [[Btr]]: transcription activation in the presence of the co-activators bacillibactin or enterobactin [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed]

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>19746494,16672620,10092453,16889643,17725565,,12354229, </pubmed>

[[Category:Protein-coding genes]]

FeuA

2011-03-10T22:14:58Z

Pballin:

* '''Description:''' [[ABC transporter]] for the siderophores Fe-enterobactin and Fe-bacillibactin (binding protein), with [[YusV]] as ATPase 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''feuA''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || [[ABC transporter]] for the siderophores Fe-enterobactin and Fe-bacillibactin (binding protein)
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || iron acquisition
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 34 kDa, 8.018
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 951 bp, 317 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[feuB]]'', ''[[btr]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB11939]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' [[Image:feuA_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[ABC transporters]]}},
{{SubtiWiki category|[[acquisition of iron]]}},
{{SubtiWiki category|[[iron metabolism]]}},
{{SubtiWiki category|[[membrane proteins]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[Btr regulon]]}},
{{SubtiWiki regulon|[[CitB regulon]]}},
{{SubtiWiki regulon|[[Fur regulon]]}}

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU01630

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/feuABC-ybbA.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10835]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/biological activity:'''
Substrate binding protein for the triscatecholate siderophores ferri-bacillibactin and ferri-enterobactin and part of the [[FeuA]]-[[FeuB]]-[[FeuC]]-[[YusV]] ATP-binding cassette-type transporter. Furthermore ferric complexes of L-norepinephrine are bound by this protein.

* '''Protein family:''' Fe/B12 periplasmic-binding domain (according to Swiss-Prot)

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''
Two independent non-symmetric globular domains, connected by a long alpha-helix (residues 143-164 of the mature protein).

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''
** [[YusV]]-([[FeuB]]-[[FeuC]])-[[FeuA]] {{PubMed|10092453}}

* '''Localization:'''
** associated to the membrane (via [[FeuB]]-[[FeuC]]) {{PubMed|10092453,18763711}}
** extracellular (signal peptide) [http://www.ncbi.nlm.nih.gov/pubmed/18957862 PubMed]

=== Database entries ===

* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2PHZ 2PHZ], [http://www.rcsb.org/pdb/explore.do?structureId=2WI8 2WI8], [http://www.rcsb.org/pdb/explore.do?structureId=2WHY 2WHY] (complex with ferri-bacillibactin)

* '''UniProt:''' [http://www.uniprot.org/uniprot/P40409 P40409]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU01630]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''[[feuA]]-[[feuB]]-[[feuC]]-[[ybbA]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]

* '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed]

* '''Regulation:'''
** repressed in the presence of iron ([[Fur]], [[CitB]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]
** induced in the presence of iron chelators bacillibactin or enterobactin ([[Btr]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed]

* '''Regulatory mechanism:'''
** [[Fur]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]
** [[CitB]]: binding to the iron responsive element in the absence of iron
** [[Btr]]: transcription activation in the presence of the co-activators bacillibactin or enterobactin [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed]

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>20086155,19746494,19673474,14563870,16672620,10092453,16889643,17725565,12354229,18957862 18763711, </pubmed>

[[Category:Protein-coding genes]]

CzrA

2011-03-10T22:06:57Z

Pballin:

* '''Description:''' transcriptional repressor of ''[[cadA]]'' and ''[[czcD]]'' 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''czrA ''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yozA''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || transcriptional repressor (ArsR family)
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of resistance against toxic metal cations
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 12 kDa, 5.719
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 321 bp, 107 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yobW]]'', ''[[yocA]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB13804]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' [[Image:yozA_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)]]}},
{{SubtiWiki category|[[transcription factors and their control]]}},
{{SubtiWiki category|[[resistance against toxic metals]]}}

= This gene is a member of the following [[regulons]] =
=The [[CzrA regulon]]:=
* ''[[cadA]]'', ''[[czcD]]-[[trkA]]''

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU19120

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13748]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:'''

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''
** DNA-binding activity of CzrA is inactivated by high concentrations of toxic metal ions (induction)

* '''Interactions:'''

* '''Localization:'''

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/O31844 O31844]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU19120]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:'''

* '''[[Sigma factor]]:'''

* '''Regulation:'''

* '''Regulatory mechanism:'''

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>15948947,,16430705, </pubmed>

[[Category:Protein-coding genes]]

CzcD

2011-03-10T22:03:55Z

Pballin:

* '''Description:''' cation diffusion facilitator 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''czcD''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yrdO ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || cation diffusion facilitator
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || cation efflux, resistence against Zn, Cu, Co, Ni
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 34 kDa, 5.859
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 933 bp, 311 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[trkA]]'', ''[[yrdN]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB14606]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' [[Image:czcD_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[transporters/ other]]}},
{{SubtiWiki category|[[trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)]]}},
{{SubtiWiki category|[[resistance against toxic metals]]}},
{{SubtiWiki category|[[membrane proteins]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[CzrA regulon]]}}

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU26650

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11931]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:'''

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:''' cell membrane (according to Swiss-Prot)

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/O07084 O07084]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU26650]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=
* '''Operon:''' ''[[czcD]]-[[trkA]]'' {{PubMed|15948947}}

* '''[[Sigma factor]]:'''

* '''Regulation:'''
** induced in the presence of toxic metal ions (Zn(II), Cd(II), Co(II), Ni(II) and Cu(II)) ([[CzrA]]) {{PubMed|15948947}}

* '''Regulatory mechanism:'''
** [[CzrA]]: transcription repression {{PubMed|15948947}}

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>15948947,, </pubmed>

[[Category:Protein-coding genes]]

CueR

2011-03-10T21:59:52Z

Pballin:

* '''Description:''' transcriptional regulator of the ''[[copZ]]-[[copA]]'' operon 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''cueR''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yhdQ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || transcriptional regulator ([[MerR family]])
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of the ''[[copZ]]-[[copA]]'' operon
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 16 kDa, 7.886
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 429 bp, 143 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yhdP]]'', ''[[yhdR]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB12795]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' [[Image:yhdQ_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)]]}},
{{SubtiWiki category|[[transcription factors and their control]]}},
{{SubtiWiki category|[[resistance against toxic metals]]}}

= This gene is a member of the following [[regulons]] =

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU09560

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13023]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:'''

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:'''

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/O07586 O07586]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU09560]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:'''

* '''[[Sigma factor]]:'''

* '''Regulation:'''

* '''Regulatory mechanism:'''

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>15948947,14663075,19651042 ,18048925 </pubmed>

[[Category:Protein-coding genes]]

CsoR

2011-03-10T21:58:03Z

Pballin:

* '''Description:''' transcription repressor of ''[[copZ]]-[[copA]]'' and of ''[[ycnJ]]'' 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''csoR''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yvgZ ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || transcription repressor
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || control of copper homeostasis
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 11 kDa, 7.299
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 303 bp, 101 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[copZ]]'', ''[[yvaA]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB15357]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' [[Image:yvgZ_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)]]}},
{{SubtiWiki category|[[transcription factors and their control]]}},
{{SubtiWiki category|[[resistance against toxic metals]]}}

= This gene is a member of the following [[regulons]] =

=The [[CsoR regulon]]:=
* ''[[copZ]]-[[copA]]'', ''[[ycnJ]]'', ''[[yotD]]''
=The gene=

=== Basic information ===

* '''Locus tag:''' BSU33520

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG14108]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:'''

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:''' Cu(I) ions cause release of CsoR from its operator sites

* '''Interactions:'''

* '''Localization:'''

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/O32222 O32222]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU33520]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:'''

* '''[[Sigma factor]]:'''

* '''Regulation:'''

* '''Regulatory mechanism:'''

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=
[[John Helmann]], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]

[[Mohamed Marahiel]], Marburg University, Germany [http://www.uni-marburg.de/fb15/fachgebiete/bio/marahiel?language_sync=1 homepage]

=Your additional remarks=

=References=

<pubmed>18048925,19168619, 20233928, 19168619, 19249860 </pubmed>

[[Category:Protein-coding genes]]

CorA

2011-03-10T21:55:15Z

Pballin:

* '''Description:''' general stress protein, magnesium transporter 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''corA''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yqhC , yqxL''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || magnesium transporter
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || magnesium transport
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 37 kDa, 9.536
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 951 bp, 317 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[comGA]]'', ''[[yqhB]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB14405]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' [[Image:yqxL_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[transporters/ other]]}},
{{SubtiWiki category|[[metal ion homeostasis (K, Na, Ca, Mg)]]}},
{{SubtiWiki category|[[general stress proteins (controlled by SigB)]]}},
{{SubtiWiki category|[[membrane proteins]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[LexA regulon]]}},
{{SubtiWiki regulon|[[SigB regulon]]}}

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU24740

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yqxL.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11075]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:'''

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:''' cell membrane (according to Swiss-Prot)

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P40948 P40948]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU24740]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''corA'' {{PubMed|2507524}}

* '''[[Sigma factor]]:''' [[SigB]] [http://www.ncbi.nlm.nih.gov/pubmed/15805528 PubMed]

* '''Regulation:'''
** induced by stress ([[SigB]]) [http://www.ncbi.nlm.nih.gov/pubmed/15805528 PubMed]
** induced upon DNA damage ([[LexA]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/16267290 PubMed]

* '''Regulatory mechanism:'''
** [[LexA]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/16267290 PubMed]

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>15231793,15856219,2507524 ,16267290,15805528, </pubmed>

[[Category:Protein-coding genes]]

CopZ

2011-03-10T21:52:43Z

Pballin:

* '''Description:''' copper transport protein, metallochaperone 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''copZ''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yvgY ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || copper transport protein, metallochaperone
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || resistance to copper
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 7 kDa, 4.162
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 207 bp, 69 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[copA]]'', ''[[csoR]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB15356]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' [[Image:yvgY_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[transporters/ other]]}},
{{SubtiWiki category|[[trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)]]}},
{{SubtiWiki category|[[resistance against toxic metals]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[CsoR regulon]]}}

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU33510

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG14107]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:'''

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):''' carries a tetranuclear Cu(I) cluster (as [Cu4(S-Cys)4(N-His)2] cluster) {{PubMed|19746989}}

* '''Effectors of protein activity:'''

* '''Interactions:''' [[CopA]]-[[CopZ]], for the transfer of the Cu(I) cluster {{PubMed|19751213}}

* '''Localization:''' cytoplasm (according to Swiss-Prot)

=== Database entries ===

* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2QIF 2QIF]

* '''UniProt:''' [http://www.uniprot.org/uniprot/O32221 O32221]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU33510]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=
* '''Operon:''' ''[[copZ]]-[[copA]]'' {{PubMed|12779235}}

* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|12779235}}
* '''Regulation:'''
** induced by copper ([[CsoR]]) {{PubMed|18048925,12779235}}

* '''Regulatory mechanism:'''
** [[CsoR]]: transcription repression {{PubMed|18048925}}

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=
[[John Helmann]], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]

=Your additional remarks=

=References=

<pubmed>18361527,11922674,12590580,14663075,12779235,12644235,18048925,19170606,14514665,14711369, 15212800 19170606 19746989 19751213 </pubmed>

[[Category:Protein-coding genes]]

CopA

2011-03-10T21:50:36Z

Pballin:

* '''Description:''' copper-transporting ATPase, resistance to copper 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''copA''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yvgX ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || copper transporting ATPase
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || copper export
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 85 kDa, 5.484
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 2409 bp, 803 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[cadA]]'', ''[[copZ]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB15355]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' [[Image:yvgX_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[transporters/ other]]}},
{{SubtiWiki category|[[trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)]]}},
{{SubtiWiki category|[[resistance against toxic metals]]}},
{{SubtiWiki category|[[membrane proteins]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[CsoR regulon]]}}

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU33500

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG14106]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:''' ATP + H2O + Cu1+(In) = ADP + phosphate + Cu1+(Out) (according to Swiss-Prot)

* '''Protein family:''' Type IB subfamily (according to Swiss-Prot)

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:''' [[CopA]]-[[CopZ]], for the transfer of the Cu(I) cluster {{PubMed|19751213}}

* '''Localization:''' cell membrane (according to Swiss-Prot)

=== Database entries ===

* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2RML 2RML] ( N-terminal soluble domain)

* '''UniProt:''' [http://www.uniprot.org/uniprot/O32220 O32220]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU33500]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=
* '''Operon:''' ''[[copZ]]-[[copA]]'' {{PubMed|12779235}}

* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|12779235}}
* '''Regulation:'''
** induced by copper ([[CsoR]]) {{PubMed|18048925,12779235}}

* '''Regulatory mechanism:'''
** [[CsoR]]: transcription repression {{PubMed|18048925}}

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=
[[John Helmann]], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]

=Your additional remarks=

=References=

<pubmed>19751213 11922674,12590580,14663075,12779235,12644235,18048925,14514665,14711369, 19378562 15212800 20233928 </pubmed>

[[Category:Protein-coding genes]]

CitM

2011-03-10T21:44:58Z

Pballin:

* '''Description:''' Mg2+-citrate transporter 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''citM''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yflO ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || Mg2+-citrate transporter
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || citrate uptake
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://subtiwiki.uni-goettingen.de/pathways/carbon_flow.html Central C-metabolism]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 45 kDa, 6.227
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1299 bp, 433 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yflP]]'', ''[[yflN]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB12590]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' [[Image:citM_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[transporters/ other]]}},
{{SubtiWiki category|[[utilization of specific carbon sources]]}},
{{SubtiWiki category|[[membrane proteins]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[CcpA regulon]]}},
{{SubtiWiki regulon|[[CitT regulon]]}}

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU07610

===Phenotypes of a mutant ===
no growth with citrate as sole carbon source {{PubMed|10972810}}

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11832]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:''' View classification (according to Swiss-Prot)

* '''Paralogous protein(s):''' [[CitH]]

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:''' cell membrane (according to Swiss-Prot)

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P55069 P55069]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU07610]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''[[citM]]-[[yflN]]'' {{PubMed|10972810}}

* '''[[Sigma factor]]:'''

* '''Regulation:'''
** induced by citrate ([[CitT]]) {{PubMed|10972810}}
** repressed by glucose ([[CcpA]]) {{PubMed|10972810}}

* '''Regulatory mechanism:'''
** [[CitT]]: transcription activation {{PubMed|10972810}}
** [[CcpA]]: transcription repression {{PubMed|10972810}}

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>16842348,11891560,10972810,11053381,3127276,12375105,8892821,12533460,12670692,11029430,12427932, </pubmed>

[[Category:Protein-coding genes]]

CitH

2011-03-10T21:41:49Z

Pballin:

* '''Description:''' secondary transporter of divalent metal ions/citrate complexes 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''citH''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yxiQ ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || secondary transporter of divalent metal ions/citrate complexes
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || citrate uptake
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 45 kDa, 9.278
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1278 bp, 426 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[katE]]'', ''[[bglS]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB15932]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|-
|-
|colspan="2" | '''Genetic context''' [[Image:citH_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[transporters/ other]]}},
{{SubtiWiki category|[[utilization of specific carbon sources]]}},
{{SubtiWiki category|[[membrane proteins]]}}

= This gene is a member of the following [[regulons]] =

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU39060

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11146]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:'''

* '''Paralogous protein(s):''' [[CitM]]

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:''' cell membrane (according to Swiss-Prot)

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P42308 P42308]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU39060]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:'''

* '''[[Sigma factor]]:'''

* '''Regulation:'''

* '''Regulatory mechanism:'''

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>8892821,,11053381,, </pubmed>

[[Category:Protein-coding genes]]

CadA

2011-03-10T21:38:50Z

Pballin:

* '''Description:''' cadmium transporting ATPase, resistance to cadmium 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''cadA''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yvgW ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || cadmium transporting ATPase
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || cadmium export
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 75 kDa, 5.998
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 2106 bp, 702 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[bdbD]]'', ''[[copA]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB15354]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' [[Image:yvgW_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[transporters/ other]]}},
{{SubtiWiki category|[[resistance against toxic metals]]}},
{{SubtiWiki category|[[membrane proteins]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[CzrA regulon]]}}

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU33490

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG14105]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:''' ATP + H2O + Cd2+(In) = ADP + phosphate + Cd2+(Out) (according to Swiss-Prot)

* '''Protein family:''' Type IB subfamily (according to Swiss-Prot)

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:''' cell membrane (according to Swiss-Prot)

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/O32219 O32219]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU33490]

* '''E.C. number:''' [http://www.expasy.org/enzyme/3.6.3.3 3.6.3.3]

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''cadA'' {{PubMed|12779235}}

* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|12779235}}

* '''Regulation:'''
** induced by toxic metal ions (Zn(II), Cd(II), Co(II), Ni(II) and Cu(II)) ([[CzrA]]) {{PubMed|12779235,15948947}}

* '''Regulatory mechanism:'''
** [[CzrA]]: transcription repression {{PubMed|15948947}}

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=
[[John Helmann]], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]

=Your additional remarks=

=References=

<pubmed>15948947,12779235,,11934502 , </pubmed>

[[Category:Protein-coding genes]]

Btr

2011-03-10T21:34:51Z

Pballin:

* '''Description:''' transcription activator (AraC family DNA-binding domain fused to [[FeuA]]-like substrate-binding domain), regulation of the ''[[feuA]]-[[feuB]]-[[feuC]]-[[ybbA]]'' operon 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''btr''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ybbB, yzbC''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || transcription activator ([[AraC]] family)
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of iron acquisition
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 60 kDa, 6.433
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1587 bp, 529 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[feuA]]'', ''[[ybbC]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB11940]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' [[Image:ybbB_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[acquisition of iron]]}},
{{SubtiWiki category|[[iron metabolism]]}},
{{SubtiWiki category|[[transcription factors and their control]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[Fur regulon]]}}
=The [[Btr regulon]]:=
* ''[[feuA]]-[[feuB]]-[[feuC]]-[[ybbA]]''

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU01640

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ybbB.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10834]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:''' transcription activation of the ''[[feuA]]-[[feuB]]-[[feuC]]-[[ybbA]]'' operon in the presence of bacillibactin or enterobactin [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed]

* '''Protein family:'''

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):''' enterobactin, bacillibactin (co-activators) [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed]

* '''Effectors of protein activity:''' enterobactin, bacillibactin (co-activators) [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed]

* '''Interactions:'''

* '''Localization:'''

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P40408 P40408]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU01640]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''btr'' {{PubMed|12354229}}

* '''[[Sigma factor]]:'''

* '''Regulation:'''
** expressed under conditions of iron starvation ([[Fur]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]

* '''Regulatory mechanism:'''
** [[Fur]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]

* '''Additional information:''' the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>12884008,17725565,,12354229, </pubmed>

[[Category:Protein-coding genes]]

ArsR

2011-03-10T21:32:03Z

Pballin:

* '''Description:''' arsenic resistance operon repressor 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''arsR''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yqcJ ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || transcription repressor
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of as (III) efflux
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 12 kDa, 4.883
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 315 bp, 105 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yqcK]]'', ''[[yqcI]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB14522]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' [[Image:arsR_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[transcription factors and their control]]}},
{{SubtiWiki category|[[resistance against toxic metals]]}},
{{SubtiWiki category|[[Skin element]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[ArsR regulon]]}},
{{SubtiWiki regulon|[[SigF regulon]]}}
=The [[ArsR regulon]]=
* ''[[arsR]]-[[yqcK]]-[[arsB]]-[[arsC]]''

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU25810

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/arsR-yqcK-arsBC.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11301]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:'''

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:'''

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P45949 P45949]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU25810]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=
* '''Operon:''' ''[[arsR]]-[[yqcK]]-[[arsB]]-[[arsC]]'' {{PubMed|9537360}}

* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|9537360}}, [[SigF]] {{PubMed|16497325}}

* '''Regulation:'''
** expressed early during sporulation in the forespore ([[SigF]]) {{PubMed|16497325}}
** expressed in the presence of toxic metal ions (As(III), Cd(II) and Ag(I)) ([[ArsR]]) {{PubMed|9537360}}

* '''Regulatory mechanism:'''
** [[ArsR]]: transcription repression {{PubMed|9537360}}

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>15948947,9537360,,16497325, </pubmed>

[[Category:Protein-coding genes]]

AseA

2011-03-10T21:28:05Z

Pballin:

* '''Description:''' As(III) efflux pump 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''aseA''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ydfA''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || As(III) efflux pump
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || resistance to arsenite
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 47 kDa, 8.968
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1305 bp, 435 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[aseR]]'', ''[[ydfB]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB12341]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' [[Image:ydfA_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[transporters/ other]]}},
{{SubtiWiki category|[[resistance against toxic metals]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[AseR regulon]]}}

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU05340

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG12148]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:'''

* '''Paralogous protein(s):''' [[YwrK]]

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:'''

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P96678 P96678]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU05340]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:'''

* '''[[Sigma factor]]:'''

* '''Regulation:'''
** induced by As(III) ([[AseR]]) {{PubMed|15948947}}

* '''Regulatory mechanism:'''
** [[AseR]]: transcription repression {{PubMed|15948947}}

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>15948947,, </pubmed>

[[Category:Protein-coding genes]]

ArsB

2011-03-10T21:25:30Z

Pballin:

* '''Description:''' extrusion of arsenite 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''arsB''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yqcL ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || arsenite exporter
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || detoxification of arsenate and arsenite
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 38 kDa, 9.773
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1038 bp, 346 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[arsC]]'', ''[[yqcK]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB14520]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|-
|-
|colspan="2" | '''Genetic context''' [[Image:arsB_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[transporters/ other]]}},
{{SubtiWiki category|[[resistance against toxic metals]]}},
{{SubtiWiki category|[[Skin element]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[ArsR regulon]]}},
{{SubtiWiki regulon|[[SigF regulon]]}}

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU25790

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/arsR-yqcK-arsBC.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11303]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:''' ACR3 family (according to Swiss-Prot)

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:'''

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P45946 P45946]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU25790]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=
* '''Operon:''' ''[[arsR]]-[[yqcK]]-[[arsB]]-[[arsC]]'' {{PubMed|9537360}}

* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|9537360}}, [[SigF]] {{PubMed|16497325}}

* '''Regulation:'''
** expressed early during sporulation in the forespore ([[SigF]]) {{PubMed|16497325}}
** expressed in the presence of toxic metal ions (As(III), Cd(II) and Ag(I)) ([[ArsR]]) {{PubMed|9537360}}

* '''Regulatory mechanism:'''
** [[ArsR]]: transcription repression {{PubMed|9537360}}

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>9537360,16497325,,9537360, </pubmed>

[[Category:Protein-coding genes]]

ArsB

2011-03-10T21:21:20Z

Pballin:

* '''Description:''' extrusion of arsenite 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''arsB''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yqcL ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || arsenite exporter
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || detoxification of arsenate and arsenite
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 38 kDa, 9.773
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1038 bp, 346 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[arsC]]'', ''[[yqcK]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB14520]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|-
|-
|colspan="2" | '''Genetic context''' [[Image:arsB_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[transporters/ other]]}},
{{SubtiWiki category|[[resistance against toxic metals]]}},
{{SubtiWiki category|[[Skin element]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[ArsR regulon]]}},
{{SubtiWiki regulon|[[SigF regulon]]}}

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU25790

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/arsR-yqcK-arsBC.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11303]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:''' ACR3 family (according to Swiss-Prot)

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:'''

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P45946 P45946]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU25790]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=
* '''Operon:''' ''[[arsR]]-[[yqcK]]-[[arsB]]-[[arsC]]'' {{PubMed|9537360}}

* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|9537360}}, [[SigF]] {{PubMed|16497325}}

* '''Regulation:'''
** expressed early during sporulation in the forespore ([[SigF]]) {{PubMed|16497325}}
** expressed in the presence of toxic metal ions (As(III), Cd(II) and Ag(I)) ([[ArsR]]) {{PubMed|9537360}}

* '''Regulatory mechanism:'''
** [[ArsR]]: transcription repression {{PubMed|9537360}}

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>9537360,16497325,,9537360, </pubmed>

[[Category:Protein-coding genes]]

ArsB

2011-03-10T21:18:31Z

Pballin:

* '''Description:''' extrusion of arsenite 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''arsB''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yqcL ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || arsenite exporter
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || detoxification of arsenate and arsenite
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 38 kDa, 9.773
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1038 bp, 346 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[arsC]]'', ''[[yqcK]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB14520]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|-
|-
|colspan="2" | '''Genetic context''' [[Image:arsB_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[transporters/ other]]}},
{{SubtiWiki category|[[resistance against toxic metals]]}},
{{SubtiWiki category|[[Skin element]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[ArsR regulon]]}},
{{SubtiWiki regulon|[[SigF regulon]]}}

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU25790

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/arsR-yqcK-arsBC.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11303]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:''' ACR3 family (according to Swiss-Prot)

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:'''

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P45946 P45946]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU25790]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=
* '''Operon:''' ''[[arsR]]-[[yqcK]]-[[arsB]]-[[arsC]]'' {{PubMed|9537360}}

* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|9537360}}, [[SigF]] {{PubMed|16497325}}

* '''Regulation:'''
** expressed early during sporulation in the forespore ([[SigF]]) {{PubMed|16497325}}
** expressed in the presence of toxic metal ions (As(III), Cd(II) and Ag(I)) ([[ArsR]]) {{PubMed|9537360}}

* '''Regulatory mechanism:'''
** [[ArsR]]: transcription repression {{PubMed|9537360}}

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>9537360,16497325,,9537360, </pubmed>

[[Category:Protein-coding genes]]

ArsB

2011-03-10T21:14:21Z

Pballin:

* '''Description:''' extrusion of arsenite 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''arsB''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yqcL ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || arsenite exporter
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || detoxification of arsenate and arsenite
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: http://cellpublisher.gobics.de/view/GqbblRJkBH_metal ion homeostasis]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 38 kDa, 9.773
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1038 bp, 346 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[arsC]]'', ''[[yqcK]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB14520]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|-
|-
|colspan="2" | '''Genetic context''' [[Image:arsB_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[transporters/ other]]}},
{{SubtiWiki category|[[resistance against toxic metals]]}},
{{SubtiWiki category|[[Skin element]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[ArsR regulon]]}},
{{SubtiWiki regulon|[[SigF regulon]]}}

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU25790

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/arsR-yqcK-arsBC.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11303]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:''' ACR3 family (according to Swiss-Prot)

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:'''

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P45946 P45946]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU25790]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=
* '''Operon:''' ''[[arsR]]-[[yqcK]]-[[arsB]]-[[arsC]]'' {{PubMed|9537360}}

* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|9537360}}, [[SigF]] {{PubMed|16497325}}

* '''Regulation:'''
** expressed early during sporulation in the forespore ([[SigF]]) {{PubMed|16497325}}
** expressed in the presence of toxic metal ions (As(III), Cd(II) and Ag(I)) ([[ArsR]]) {{PubMed|9537360}}

* '''Regulatory mechanism:'''
** [[ArsR]]: transcription repression {{PubMed|9537360}}

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>9537360,16497325,,9537360, </pubmed>

[[Category:Protein-coding genes]]

ArsB

2011-03-10T21:09:30Z

Pballin:

* '''Description:''' extrusion of arsenite 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''arsB''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yqcL ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || arsenite exporter
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || detoxification of arsenate and arsenite
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: http://cellpublisher.gobics.de/view/GqbblRJkBH/ (metal ion homeostasis)'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 38 kDa, 9.773
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1038 bp, 346 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[arsC]]'', ''[[yqcK]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB14520]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|-
|-
|colspan="2" | '''Genetic context''' [[Image:arsB_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[transporters/ other]]}},
{{SubtiWiki category|[[resistance against toxic metals]]}},
{{SubtiWiki category|[[Skin element]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[ArsR regulon]]}},
{{SubtiWiki regulon|[[SigF regulon]]}}

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU25790

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/arsR-yqcK-arsBC.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11303]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:''' ACR3 family (according to Swiss-Prot)

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:'''

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P45946 P45946]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU25790]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=
* '''Operon:''' ''[[arsR]]-[[yqcK]]-[[arsB]]-[[arsC]]'' {{PubMed|9537360}}

* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|9537360}}, [[SigF]] {{PubMed|16497325}}

* '''Regulation:'''
** expressed early during sporulation in the forespore ([[SigF]]) {{PubMed|16497325}}
** expressed in the presence of toxic metal ions (As(III), Cd(II) and Ag(I)) ([[ArsR]]) {{PubMed|9537360}}

* '''Regulatory mechanism:'''
** [[ArsR]]: transcription repression {{PubMed|9537360}}

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>9537360,16497325,,9537360, </pubmed>

[[Category:Protein-coding genes]]

ArsB

2011-03-10T21:06:50Z

Pballin:

* '''Description:''' extrusion of arsenite 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''arsB''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yqcL ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || arsenite exporter
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || detoxification of arsenate and arsenite
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: http://cellpublisher.gobics.de/view/GqbblRJkBH/'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 38 kDa, 9.773
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1038 bp, 346 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[arsC]]'', ''[[yqcK]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB14520]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|-
|-
|colspan="2" | '''Genetic context''' [[Image:arsB_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[transporters/ other]]}},
{{SubtiWiki category|[[resistance against toxic metals]]}},
{{SubtiWiki category|[[Skin element]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[ArsR regulon]]}},
{{SubtiWiki regulon|[[SigF regulon]]}}

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU25790

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/arsR-yqcK-arsBC.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11303]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:''' ACR3 family (according to Swiss-Prot)

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:'''

=== Database entries ===

* '''Structure:'''

* '''UniProt:''' [http://www.uniprot.org/uniprot/P45946 P45946]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU25790]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=
* '''Operon:''' ''[[arsR]]-[[yqcK]]-[[arsB]]-[[arsC]]'' {{PubMed|9537360}}

* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|9537360}}, [[SigF]] {{PubMed|16497325}}

* '''Regulation:'''
** expressed early during sporulation in the forespore ([[SigF]]) {{PubMed|16497325}}
** expressed in the presence of toxic metal ions (As(III), Cd(II) and Ag(I)) ([[ArsR]]) {{PubMed|9537360}}

* '''Regulatory mechanism:'''
** [[ArsR]]: transcription repression {{PubMed|9537360}}

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>9537360,16497325,,9537360, </pubmed>

[[Category:Protein-coding genes]]