2010-01-06T16:26:59Z

Puma: /* References */

* '''Description:''' similar to multidrug resistance protein 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''ymfD''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || unknown
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || unknown
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 13 kDa, 10.069
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 372 bp, 124 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ymfC]]'', ''[[ymfF]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB13555]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|-
|-
|colspan="2" | '''Genetic context''' [[Image:ymfD_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU16825

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13424]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:''' major facilitator superfamily (according to Swiss-Prot)

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:''' cell membrane (according to Swiss-Prot)

=== Database entries ===

* '''Structure:'''

* '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/O31762 O31762]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU16820]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:'''

* '''[[Sigma factor]]:''' [[SigG]] {{PubMed|15699190}}

* '''Regulation:'''

* '''Regulatory mechanism:'''

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=
<pubmed>18502870</pubmed>
[[Category:Protein-coding genes]]

Mohamed Marahiel

2010-01-06T15:38:26Z

Puma: /* Main research interests */

= Lab head: Mohamed A. Marahiel=
'''Additional information'''
* [mailto:marahiel@staff.uni-marburg.de send mail]
* location: Marburg, Germany
* Homepage: [http://www.uni-marburg.de/fb15/ag-marahiel/Prof.%20Dr.%20Mohamed%20A.%20Marahiel link]

= Publications =
[http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Marahiel%2BMA%22%5Bau%5D&dispmax=50 Pubmed]

= Main research interests =
nonribosomal peptide synthesis, bacterial metal homeostasis, bacterial lasso peptides, cold shock response, gene regulation

= Open positions =

2010-01-04T16:35:06Z

Puma: /* References */

* '''Description:''' ABC-transporter for the siderophores enterobactin and bacillibactin (binding protein), with [[YusV]] as ATPase 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''feuA''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || ABC-transporter for the siderophores enterobactin and bacillibactin (binding protein)
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || iron acquisition
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 34 kDa, 8.018
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 951 bp, 317 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[feuB]]'', ''[[btr]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB11939]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' [[Image:feuA_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU01630

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/feuABC-ybbA.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10835]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:''' Fe/B12 periplasmic-binding domain (according to Swiss-Prot)

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:''' cell membrane (according to Swiss-Prot), extracellular (signal peptide) [http://www.ncbi.nlm.nih.gov/pubmed/18957862 PubMed], membrane [http://www.ncbi.nlm.nih.gov/pubmed/18763711 PubMed]

=== Database entries ===

* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2PHZ 2PHZ], [http://www.rcsb.org/pdb/explore.do?structureId=2WI8 2WI8], [http://www.rcsb.org/pdb/explore.do?structureId=2WHY 2WHY] (complex with ferri-bacillibactin)

* '''UniProt:''' [http://www.uniprot.org/uniprot/P40409 P40409]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU01630]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''[[feuA]]-[[feuB]]-[[feuC]]-[[ybbA]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]

* '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed]

* '''Regulation:'''
** repressed in the presence of iron ([[Fur]], [[CitB]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]
** induced in the presence of iron chelators bacillibactin or enterobactin ([[Btr]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed]

* '''Regulatory mechanism:'''
** [[Fur]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]
** [[CitB]]: binding to the iron responsive element in the absence of iron
** [[Btr]]: transcription activation in the presence of the co-activators bacillibactin or enterobactin [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed]

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>19746494,19673474,14563870,16672620,10092453,16889643,17725565,12354229,18957862 18763711, </pubmed>

[[Category:Protein-coding genes]]

FeuA

2009-10-14T09:54:46Z

Puma:

* '''Description:''' ABC-transporter for the siderophores enterobactin and bacillibactin (binding protein), with [[YusV]] as ATPase 

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''feuA''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || ABC-transporter for the siderophores enterobactin and bacillibactin (binding protein)
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || iron acquisition
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 34 kDa, 8.018
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 951 bp, 317 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[feuB]]'', ''[[btr]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB11939]+-newId sequences] (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' [[Image:feuA_context.gif]]
<div align="right"> This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</div>
|-
|}

__TOC__

 

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU01630

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/feuABC-ybbA.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10835]

=== Additional information===

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:''' Fe/B12 periplasmic-binding domain (according to Swiss-Prot)

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:''' cell membrane (according to Swiss-Prot), extracellular (signal peptide) [http://www.ncbi.nlm.nih.gov/pubmed/18957862 PubMed], membrane [http://www.ncbi.nlm.nih.gov/pubmed/18763711 PubMed]

=== Database entries ===

* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2PHZ 2PHZ], [http://www.rcsb.org/pdb/explore.do?structureId=2WI8 2WI8], [http://www.rcsb.org/pdb/explore.do?structureId=2WHY 2WHY] (complex with ferri-bacillibactin)

* '''UniProt:''' [http://www.uniprot.org/uniprot/P40409 P40409]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU01630]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''[[feuA]]-[[feuB]]-[[feuC]]-[[ybbA]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]

* '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed]

* '''Regulation:'''
** repressed in the presence of iron ([[Fur]], [[CitB]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]
** induced in the presence of iron chelators bacillibactin or enterobactin ([[Btr]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed]

* '''Regulatory mechanism:'''
** [[Fur]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]
** [[CitB]]: binding to the iron responsive element in the absence of iron
** [[Btr]]: transcription activation in the presence of the co-activators bacillibactin or enterobactin [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed]

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>19746494,14563870,16672620,10092453,16889643,17725565,12354229,18957862 18763711, </pubmed>

[[Category:Protein-coding genes]]