|
|
| (66 intermediate revisions by 3 users not shown) |
| Line 1: |
Line 1: |
| − | Biofilms are the result of the multicellular lifestyle of ''B. subtilis''. They are characterized by the formation of a matrix polysaccharide and an amyloid-like protein, [[TasA]].
| |
| | | | |
| − | {| align="right" border="1" cellpadding="2"
| |
| − | |-
| |
| − | |style="background:#ABCDEF;" align="center"|'''Gene name'''
| |
| − | |''sinR''
| |
| − | |-
| |
| − | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''sin, flaD ''
| |
| − | |-
| |
| − | |style="background:#ABCDEF;" align="center"| '''Essential''' || no
| |
| − | |-
| |
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || transcriptional regulator of post-exponential-phase responses genes
| |
| − | |-
| |
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || control of [[biofilm formation]]
| |
| − | |-
| |
| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/biofilm.html Biofilm], [http://subtiwiki.uni-goettingen.de/pathways/carbon_flow.html Central C-metabolism]'''
| |
| − | |-
| |
| − | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 12 kDa, 7.177
| |
| − | |-
| |
| − | |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 333 bp, 111 aa
| |
| − | |-
| |
| − | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[sinI]]'', ''[[tasA]]''
| |
| − | |-
| |
| − | |colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB14392]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
| |
| − | |-
| |
| − | |colspan="2" | '''Genetic context''' <br/> [[Image:sinR_context.gif]]
| |
| − | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
| |
| − | |-
| |
| − | |}
| |
| | | | |
| − | __TOC__
| + | [[File:Example.jpg]] |
| − | | |
| − | ==[http://subtiwiki.uni-goettingen.de/pathways/biofilm.html Biofilm formation in ''Subti''Pathways]==
| |
| − | | |
| − | ==Labs working on biofilm formation==
| |
| − | * [[Daniel Kearns]]
| |
| − | * [[Oscar Kuipers]]
| |
| − | * [[Beth Lazazzera]]
| |
| − | * [[Richard Losick]]
| |
| − | * [[Nicola Stanley-Wall]]
| |
| − | | |
| − | ==Key genes and operons involved in biofilm formation==
| |
| − | * matrix polysaccharide synthesis:
| |
| − | ** ''[[epsA]]-[[epsB]]-[[epsC]]-[[epsD]]-[[epsE]]-[[epsF]]-[[epsG]]-[[epsH]]-[[epsI]]-[[epsJ]]-[[epsK]]-[[epsL]]-[[epsM]]-[[epsN]]-[[epsO]]''
| |
| − | * amyloid protein synthesis
| |
| − | ** ''[[yqxM]]-[[sipW]]-[[tasA]]''
| |
| − | * regulation
| |
| − | ** [[SlrR]]
| |
| − | ** [[SlrA]]
| |
| − | ** [[SinR]]
| |
| − | ** [[SinI]]
| |
| − | ** [[PtkA]]
| |
| − | ** [[TkmA]]
| |
| − | ** [[PtpZ]]
| |
| − | ** [[DegU]]
| |
| − | ** [[RacX]]
| |
| − | * biofilm disassembly
| |
| − | ** [[YlmE]]
| |
| − | * other proteins required for biofilm formation
| |
| − | ** [[SpeA]]
| |
| − | ** [[YmcA]]
| |
| − | ** [[YxaB]]
| |
| − | | |
| − | ==Key reviews==
| |
| − | <pubmed>19054118 19054118 16787201 9891794 20890834 </pubmed>
| |
| − | * additional reviews: {{PubMed|20735481}}
| |
