Difference between revisions of "WapA"
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= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
{{SubtiWiki regulon|[[DegU regulon]]}}, | {{SubtiWiki regulon|[[DegU regulon]]}}, | ||
| + | {{SubtiWiki regulon|[[WalR regulon]]}}, | ||
{{SubtiWiki regulon|[[YvrHb regulon]]}} | {{SubtiWiki regulon|[[YvrHb regulon]]}} | ||
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=== Additional information=== | === Additional information=== | ||
* A mutation was found in this gene after evolution under relexed selection for sporulation {{PubMed|21821766}} | * A mutation was found in this gene after evolution under relexed selection for sporulation {{PubMed|21821766}} | ||
| − | |||
=The protein= | =The protein= | ||
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* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''[[Domains]]:''' |
** cell wall binding domain as retention signal | ** cell wall binding domain as retention signal | ||
** C-terminal toxic domain with RNase activity (cleaves tRNAs) {{PubMed|23572593}} | ** C-terminal toxic domain with RNase activity (cleaves tRNAs) {{PubMed|23572593}} | ||
| Line 88: | Line 88: | ||
* '''Modification:''' | * '''Modification:''' | ||
| − | * ''' | + | * '''[[Cofactors]]:''' |
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
Revision as of 11:33, 29 December 2013
- Description: cell wall-associated protein precursor, contact-dependent growth inhibition protein
| Gene name | wapA |
| Synonyms | |
| Essential | no |
| Product | cell wall-associated protein precursor |
| Function | intercellular competition |
| Gene expression levels in SubtiExpress: wapA | |
| Interactions involving this protein in SubtInteract: WapA | |
| MW, pI | 258 kDa, 6.131 |
| Gene length, protein length | 7002 bp, 2334 aa |
| Immediate neighbours | yxxG, yxxF |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
cell wall/ other, toxins, antitoxins and immunity against toxins
This gene is a member of the following regulons
DegU regulon, WalR regulon, YvrHb regulon
The gene
Basic information
- Locus tag: BSU39230
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
- A mutation was found in this gene after evolution under relexed selection for sporulation PubMed
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- the C-terminal toxic domain has RNase activity (cleaves tRNAs) PubMed
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- cell wall binding domain as retention signal
- C-terminal toxic domain with RNase activity (cleaves tRNAs) PubMed
- Modification:
- Localization:
- extracellular (signal peptide), cell wall binding domain as retention signal, major constituent of the secretome PubMed
Database entries
- Structure:
- UniProt: Q07833
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
