aroB
168
3-dehydroquinate synthase
locus
BSU_22700
Molecular weight
40.66 kDa
pI
6.94
function
biosynthesis of aromatic amino acids
product
3-dehydroquinate synthase
essential
no
ec
4.2.3.4
synonyms
aroB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0337 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,378,012 2,379,100
The protein
Catalyzed reaction/ biological activity
7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate --> 3-dehydroquinate + phosphate (according to UniProt)
Protein family
sugar phosphate cyclases superfamily (single member, according to UniProt)
Structure
[PDB|3CLH] (from ''Helicobacter pylori'', 36% identity) [Pubmed|18503755]
[AF|P31102]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|1217807AE3AE3A654BA0DD4AF5ADF1CEE62632B6|cheR]-[gene|9712D0E655289C97315314BDEE1A0DF2ED2ADCA2|aroF]-[gene|58B782C1F7931F8671161455E65E3D5C72B0BB9C|aroB]-[gene|5C2F7F9F5FCBFEDF77AC41725EFDA0FAF0FC3BC1|aroH]
description
[pubmed|22383849]
genes
[gene|9712D0E655289C97315314BDEE1A0DF2ED2ADCA2|aroF]-[gene|58B782C1F7931F8671161455E65E3D5C72B0BB9C|aroB]-[gene|5C2F7F9F5FCBFEDF77AC41725EFDA0FAF0FC3BC1|aroH]
description
[pubmed|21815947]
Biological materials
Mutant
1A613 ( ''aroB''::''erm''), [Pubmed|3015878], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A613&Search=1A613 BGSC]
BKE22700 ([gene|58B782C1F7931F8671161455E65E3D5C72B0BB9C|aroB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE22700 BGSC] and in [wiki|Jörg Stülke]'s lab, [Pubmed|28189581], upstream reverse: _UP1_AGTTTGAACATGCAGTGTCT, downstream forward: _UP4_AAATGGCGATTGGAGGAGAC
BKK22700 ([gene|58B782C1F7931F8671161455E65E3D5C72B0BB9C|aroB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK22700 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AGTTTGAACATGCAGTGTCT, downstream forward: _UP4_AAATGGCGATTGGAGGAGAC
References
Reviews
Original Publications
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Time of last update: 2025-05-08 14:28:51
Author of last update: Melvin.boenninger