uvrC
168
excinuclease ABC (subunit C), required for transcription-dependent asymmetry in mutation rates of genes in the two orientations
locus
BSU_28490
Molecular weight
69.28 kDa
pI
9.5
function
DNA repair after UV damage
product
excinuclease ABC (subunit C)
essential
no
ec
null
synonyms
uvrC, uvrB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0322 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,911,116 2,912,888
The protein
Protein family
uvrC family (single member, according to UniProt)
[wiki|Domains]
[wiki|GIY-YIG-domain] (aa 14-91) (according to UniProt)
[wiki|UVR domain] (aa 196-231) (according to UniProt)
Structure
[PDB|3C65] (5' endonuclease domain, Geobacillus stearothermophilus)
[AF|P14951]
Expression and Regulation
Operons
genes
[gene|6624AA675E9E52FFABFF26055F63471AEF881CC5|uvrC]
description
[Pubmed|16267290]
regulation
induced upon DNA damage ([protein|search|LexA]) [Pubmed|16267290]
regulatory mechanism
[protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA]: repression, [Pubmed|16267290]], in [regulon|protein:D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA regulon]
Biological materials
Mutant
GP3542 (Δ[gene|6624AA675E9E52FFABFF26055F63471AEF881CC5|uvrC]::kan), available in [wiki|Jörg Stülke]'s lab
BKE28490 ([gene|6624AA675E9E52FFABFF26055F63471AEF881CC5|uvrC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE28490 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATGTTACCCTTCCTTAT, downstream forward: _UP4_TAATGTTGTCCTTTTAAATA
BKK28490 ([gene|6624AA675E9E52FFABFF26055F63471AEF881CC5|uvrC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK28490 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATGTTACCCTTCCTTAT, downstream forward: _UP4_TAATGTTGTCCTTTTAAATA
References
Reviews
Original Publications
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Time of last update: 2025-05-12 23:25:11
Author of last update: Jstuelk