forC2
168
[metabolite|formate]:[metabolite|menadione] oxidoreductase (with [protein|364BC3B51D8DF152C2DF31046D4F80595C75884B|forE2]), catalytic subunit
locus
BSU_27220
Molecular weight
108.57 kDa
pI
5.16
function
unknown
product
[metabolite|formate]:[metabolite|menadione] oxidoreductase
essential
no
ec
1.2.1.2
synonyms
yrhE
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG3383 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,781,209 2,784,151
The protein
Catalyzed reaction/ biological activity
[metabolite|formate] + NAD+ --> CO2 + NADH (according to UniProt)
Protein family
C-terminal part: [wiki|prokaryotic molybdopterin-containing oxidoreductase family] (according to UniProt)
[wiki|Domains]
2Fe-2S ferredoxin-type domain (aa 5-81) (according to UniProt)
4Fe-4S His(Cys)3-ligated-type domain (aa 81-121) (according to UniProt)
2 [wiki|4Fe-4S ferredoxin-type domain]s (aa 144-171, aa 187-216) (according to UniProt)
[wiki|4Fe-4S Mo/W bis-MGD-type domain] (aa 263-319) (according to UniProt)
[wiki|Cofactors]
4 [metabolite|4Fe-4S] cluster [pubmed|34748728]
1 [metabolite|2Fe-2S] cluster [pubmed|34748728]
molybdenum-bis(molybdopterin guanine dinucleotide) ([metabolite|Mo-bis-MGD]) [pubmed|34748728]
[metabolite|menachinone-7] [pubmed|34748728]
Structure
[PDB|8RQZ] (crystal structure of [protein|E54F39E72DC4881E886159607C2B424A41DE0D01|forC1]4-[protein|01C43D05A53BF4B0F505D9C9CCAAFA1AF9E94F87|forE1]4) [pubmed|40855134]
[PDB|8RR0] (cryo-EM structure of [protein|E54F39E72DC4881E886159607C2B424A41DE0D01|forC1]4-[protein|01C43D05A53BF4B0F505D9C9CCAAFA1AF9E94F87|forE1]4) [pubmed|40855134]
[AF|Q795Y4]
Modification
Fe-S cluster [pubmed|29292548]
Paralogous protein(s)
[protein|E54F39E72DC4881E886159607C2B424A41DE0D01|forC1]
Expression and Regulation
Operons
genes
[gene|A4304213CFC152B601B2EED2B9B3A0A3AB4E6A81|forC2]-[gene|364BC3B51D8DF152C2DF31046D4F80595C75884B|forE2]
description
[Pubmed|21815947]
additional information
term-seq has identified a potential novel regulatory RNA element including an intrinsic transcription terminator upstream of [gene|search|yrhE] [Pubmed|27120414]
Biological materials
Mutant
MGNA-A160 (yrhE::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/160 NBRP B. subtilis, Japan]
BKE27220 ([gene|A4304213CFC152B601B2EED2B9B3A0A3AB4E6A81|forC2]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE27220 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTCATATTCCCCTCCA, downstream forward: _UP4_GATTAAACGATAGGAGGAAA
BKK27220 ([gene|A4304213CFC152B601B2EED2B9B3A0A3AB4E6A81|forC2]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK27220 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTCATATTCCCCTCCA, downstream forward: _UP4_GATTAAACGATAGGAGGAAA
References
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Time of last update: 2025-09-13 13:37:00
Author of last update: Jstuelk